Blue dye for identification of sentinel nodes in breast cancer and malignant melanoma: a systematic review and meta-analysis

The combined technique (radioisotope and blue dye) is the gold standard for sentinel lymph node biopsy (SLNB) and there is wide variation in techniques and blue dyes used. We performed a systematic review and meta-analysis to assess the need for radioisotope and the optimal blue dye for SLNB. A tota...

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Bibliographic Details
Published in:Future oncology (London, England) England), 2017-02, Vol.13 (5), p.455-467
Main Authors: Peek, Mirjam CL, Charalampoudis, Petros, Anninga, Bauke, Baker, Rose, Douek, Michael
Format: Article
Language:English
Subjects:
Biopsy
blue dye
breast
Breast cancer
Breast Neoplasms - diagnosis
Coloring Agents
combined technique
Dyes
Female
Humans
iso-sulfan blue
Lymph Nodes - pathology
Lymphatic Metastasis
malignant melanoma
Melanoma
Melanoma - diagnosis
Meta-analysis
methylene blue
Neoplasm Recurrence, Local
Patent Blue V
radioisotope
Sensitivity and Specificity
sentinel lymph node biopsy
Sentinel Lymph Node Biopsy - adverse effects
Sentinel Lymph Node Biopsy - methods
Skin cancer
SLNB
Systematic review
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Summary:The combined technique (radioisotope and blue dye) is the gold standard for sentinel lymph node biopsy (SLNB) and there is wide variation in techniques and blue dyes used. We performed a systematic review and meta-analysis to assess the need for radioisotope and the optimal blue dye for SLNB. A total of 21 studies were included. The SLNB identification rates are high with all the commonly used blue dyes. Furthermore, methylene blue is superior to iso-sulfan blue and Patent Blue V with respect to false-negative rates. The combined technique remains the most accurate and effective technique for SLNB. In order to standardize the SLNB technique, comparative trials to determine the most effective blue dye and national guidelines are required.
ISSN:1479-6694
1744-8301
DOI:10.2217/fon-2016-0255