Association between SNPs and haplotypes in the METTL21C gene and peak bone mineral density and body composition in Chinese male nuclear families

The methyltransferase-like 21C gene ( METTL21C ), which is mainly expressed in muscle, can promote the differentiation of myoblasts to myotubes and reduce glucocorticoid-induced apoptosis of osteocytes. The purpose of this study was to explore the association between single nucleotide polymorphisms...

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Bibliographic Details
Published in:Journal of bone and mineral metabolism 2017-07, Vol.35 (4), p.437-447
Main Authors: Zhao, Fei, Gao, Li-hong, Li, Shan-shan, Wei, Zhan-ying, Fu, Wen-zhen, He, Jin-wei, Liu, Yu-juan, Hu, Yun-qiu, Dong, Jing, Zhang, Zhen-lin
Format: Article
Language:English
Subjects:
Absorptiometry, Photon
Androgens
Apoptosis
Asian Continental Ancestry Group - genetics
Body composition
Body Composition - genetics
Body Composition - physiology
Body fat
Body mass
Body mass index
Bone composition
Bone density
Bone Density - genetics
Bone Density - physiology
Bone mass
Bone mineral density
Dual energy X-ray absorptiometry
Female
Femur
Genetic Association Studies
Genotype
Glucocorticoids
Haplotypes
Haplotypes - genetics
Hip
Humans
Linkage Disequilibrium - genetics
Male
Medicine
Medicine & Public Health
Metabolic Diseases
Methyltransferase
Methyltransferases - genetics
Middle Aged
Multivariate Analysis
Myoblasts
Myotubes
Nuclear Family
Original Article
Orthopedics
Osteocytes
Osteoporosis
Pleiotropy
Polymorphism, Single Nucleotide - genetics
Quantitative trait loci
Single-nucleotide polymorphism
Spine (lumbar)
Trinucleotide repeats
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Summary:The methyltransferase-like 21C gene ( METTL21C ), which is mainly expressed in muscle, can promote the differentiation of myoblasts to myotubes and reduce glucocorticoid-induced apoptosis of osteocytes. The purpose of this study was to explore the association between single nucleotide polymorphisms of METTL21C and peak bone mineral density (BMD), body mass index, total fat mass (TFM), and total lean mass (TLM) in Chinese young men. Fifteen tagging single nucleotide polymorphisms were genotyped, and haplotype blocks were derived in 400 Chinese male nuclear families. The peak BMD of the lumbar and hip, TFM, and TLM were measured by dual-energy X-ray absorptiometry. The association analyses were performed by a quantitative transmission disequilibrium test. Both TLM and TFM had a significant positive effect on peak BMD, but the positive regulation of TLM was stronger than that of TFM. After 1000 permutations, significant within-family associations were found between rs9585961 and lumbar spine BMD and femoral neck BMD, rs9518810 and femoral neck BMD, and rs599976 and body mass index, TFM, and percentage fat mass (all P  
ISSN:0914-8779
1435-5604
DOI:10.1007/s00774-016-0774-7