Concurrent extrahepatic autoimmunity in autoimmune hepatitis: implications for diagnosis, clinical course and long‐term outcomes

Background Concurrent extrahepatic autoimmune disease (CEHAID) associated with autoimmune hepatitis (AIH) have been incorporated into the diagnostic criteria stipulated by the International Autoimmune Hepatitis Group (IAIHG). Large comprehensive cohort data on the extrahepatic autoimmunity in AIH re...

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Bibliographic Details
Published in:Liver international 2017-03, Vol.37 (3), p.449-457
Main Authors: Wong, Guan‐Wee, Yeong, Tian, Lawrence, David, Yeoman, Andrew D., Verma, Sumita, Heneghan, Michael A.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Antibodies
Ascites
Autoantibodies - blood
Autoimmune Diseases - classification
Autoimmune Diseases - epidemiology
autoimmune skin disease
autoimmune thyroiditis
Child
Child, Preschool
Databases, Factual
Diagnosis
Diagnostic systems
Disease
Disease Progression
extrahepatic autoimmune diseases
Family Health
family history
Female
Fibrosis
first‐degree relatives
Genetics
Hepatitis
Hepatitis, Autoimmune - complications
Humans
Liver
Male
Medical prognosis
Middle Aged
Patients
Prognosis
Retrospective Studies
Risk Factors
Skin diseases
Smooth muscle
Survival Analysis
Tertiary Care Centers
Thyroid
United Kingdom - epidemiology
Young Adult
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Summary:Background Concurrent extrahepatic autoimmune disease (CEHAID) associated with autoimmune hepatitis (AIH) have been incorporated into the diagnostic criteria stipulated by the International Autoimmune Hepatitis Group (IAIHG). Large comprehensive cohort data on the extrahepatic autoimmunity in AIH remain scanty. Aim To systematically assess features and clinical impact of CEHAID on AIH. Methods Clinical records of 562 patients with AIH from two tertiary centres in the UK were retrospectively reviewed. Results Prevalence of CEHAID in patients with AIH was 42%. Autoimmune thyroid disease was the commonest CEHAID associated with AIH (101/562, 18%). Autoimmune skin diseases were more prevalent in AIH‐2 than AIH‐1 (21.9% vs 7%, P=.009). Personal history of CEHAID was more commonly found in AIH patients with than without first‐degree family history of CEHAID [48/86 (55.8%) vs 169/446 (37.9%), P=.002]. AIH patients with CEHAID were more often women (85.2% vs 76.1%, P=.008), had higher post‐treatment IAIHG score (22 vs 20, P
ISSN:1478-3223
1478-3231
DOI:10.1111/liv.13236