Effect of Bilateral Prefrontal rTMS on Left Prefrontal NAA and Glx Levels in Schizophrenia Patients with Predominant Negative Symptoms: an Exploratory Study

• Published in: Brain stimulation 2017-01, Vol.10 (1), p.59-64
• Main Authors: Dlabac-de Lange, Jozarni J., MD, PhD, Liemburg, Edith J., PhD, Bais, Leonie, MSc, van de Poel-Mustafayeva, Aida T, de Lange-de Klerk, E.S.M., MD, PhD, Knegtering, Henderikus, MD, PhD, Aleman, André, PhD
• Format: Article
• Language: English
• Subjects: 1H-Magnetic resonance spectroscopy; Adult; Aspartic Acid - analogs & derivatives; Aspartic Acid - metabolism; Dorsolateral prefrontal cortex; Double-Blind Method; Female; Glutamate; Glutamic Acid - metabolism; Humans; Magnetic Resonance Imaging - methods; Male; Middle Aged; N-Acetyl aspartate; Negative symptoms; Neurology; Pessimism; Prefrontal Cortex - metabolism; Randomized controlled trial; Schizophrenia; Schizophrenia - diagnostic imaging; Schizophrenia - metabolism; Schizophrenia - therapy; Transcranial magnetic stimulation; Transcranial Magnetic Stimulation - methods; Treatment Outcome; Young Adult
• ISSN: 1935-861X; 1876-4754
• DOI: 10.1016/j.brs.2016.08.002

Highlights • We studied neurotransmitters concentrations changes in the left prefrontal cortex of patients with schizophrenia after bilateral prefrontal high frequency rTMS • An increase of glutamate concentration was found after active rTMS, a decrease after sham rTMS • Prefrontal rTMS did not influence N-Acetyl Aspartate concentration • High frequency prefrontal rTMS may increase prefrontal metabolism in patients with schizophrenia