Loading…
Effect of Bilateral Prefrontal rTMS on Left Prefrontal NAA and Glx Levels in Schizophrenia Patients with Predominant Negative Symptoms: an Exploratory Study
Highlights • We studied neurotransmitters concentrations changes in the left prefrontal cortex of patients with schizophrenia after bilateral prefrontal high frequency rTMS • An increase of glutamate concentration was found after active rTMS, a decrease after sham rTMS • Prefrontal rTMS did not infl...
Saved in:
| Published in: | Brain stimulation 2017-01, Vol.10 (1), p.59-64 |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c451t-f4132a4a51d555a793c03c8bf2d2324a9124468540a5a5c48e08ce4729f488d83 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c451t-f4132a4a51d555a793c03c8bf2d2324a9124468540a5a5c48e08ce4729f488d83 |
| container_end_page | 64 |
| container_issue | 1 |
| container_start_page | 59 |
| container_title | Brain stimulation |
| container_volume | 10 |
| creator | Dlabac-de Lange, Jozarni J., MD, PhD Liemburg, Edith J., PhD Bais, Leonie, MSc van de Poel-Mustafayeva, Aida T de Lange-de Klerk, E.S.M., MD, PhD Knegtering, Henderikus, MD, PhD Aleman, André, PhD |
| description | Highlights • We studied neurotransmitters concentrations changes in the left prefrontal cortex of patients with schizophrenia after bilateral prefrontal high frequency rTMS • An increase of glutamate concentration was found after active rTMS, a decrease after sham rTMS • Prefrontal rTMS did not influence N-Acetyl Aspartate concentration • High frequency prefrontal rTMS may increase prefrontal metabolism in patients with schizophrenia |
| doi_str_mv | 10.1016/j.brs.2016.08.002 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1859724886</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1935861X16302054</els_id><sourcerecordid>1859724886</sourcerecordid><originalsourceid>FETCH-LOGICAL-c451t-f4132a4a51d555a793c03c8bf2d2324a9124468540a5a5c48e08ce4729f488d83</originalsourceid><addsrcrecordid>eNp9UsFuEzEUXCEQLYUP4IJ85LKL7bV3vSAhhSotSKFUSpG4WY73LXHw2sF2QrffwsfiKAUhDpw88psZ6c28onhOcEUwaV5tqlWIFc2wwqLCmD4oTolom5K1nD3MuKt5KRry5aR4EuMGY951on1cnNC2Ibzt6tPi53wYQCfkB_TOWJUgKIuuAwzBu5RhuPm4RN6hBQzp7_-r2Qwp16NLe5tne7ARGYeWem3u_HYdwBmFrlUy4FJEP0xaH8S9H41TLqEr-Jpne0DLadwmP8bX2QzNb7fWB5V8mNAy7frpafFoUDbCs_v3rPh8Mb85f18uPl1-OJ8tSs04SeXASE0VU5z0nHOV99K41mI10J7WlKmOUMYawRlWXHHNBGChgbW0G5gQvajPipdH323w33cQkxxN1GCtcuB3URLBu5ZmbpOp5EjVwceY85DbYEYVJkmwPJQiNzKXIg-lSCxkLiVrXtzb71Yj9H8Uv1vIhDdHQo4R9gaCjDonp6E3IZcje2_-a__2H7W2xhmt7DeYIG78LricniQyUonl8nAVh6MgTY0p5qz-BeWUsyU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1859724886</pqid></control><display><type>article</type><title>Effect of Bilateral Prefrontal rTMS on Left Prefrontal NAA and Glx Levels in Schizophrenia Patients with Predominant Negative Symptoms: an Exploratory Study</title><source>ScienceDirect Journals</source><creator>Dlabac-de Lange, Jozarni J., MD, PhD ; Liemburg, Edith J., PhD ; Bais, Leonie, MSc ; van de Poel-Mustafayeva, Aida T ; de Lange-de Klerk, E.S.M., MD, PhD ; Knegtering, Henderikus, MD, PhD ; Aleman, André, PhD</creator><creatorcontrib>Dlabac-de Lange, Jozarni J., MD, PhD ; Liemburg, Edith J., PhD ; Bais, Leonie, MSc ; van de Poel-Mustafayeva, Aida T ; de Lange-de Klerk, E.S.M., MD, PhD ; Knegtering, Henderikus, MD, PhD ; Aleman, André, PhD</creatorcontrib><description>Highlights • We studied neurotransmitters concentrations changes in the left prefrontal cortex of patients with schizophrenia after bilateral prefrontal high frequency rTMS • An increase of glutamate concentration was found after active rTMS, a decrease after sham rTMS • Prefrontal rTMS did not influence N-Acetyl Aspartate concentration • High frequency prefrontal rTMS may increase prefrontal metabolism in patients with schizophrenia</description><identifier>ISSN: 1935-861X</identifier><identifier>EISSN: 1876-4754</identifier><identifier>DOI: 10.1016/j.brs.2016.08.002</identifier><identifier>PMID: 27615793</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>1H-Magnetic resonance spectroscopy ; Adult ; Aspartic Acid - analogs & derivatives ; Aspartic Acid - metabolism ; Dorsolateral prefrontal cortex ; Double-Blind Method ; Female ; Glutamate ; Glutamic Acid - metabolism ; Humans ; Magnetic Resonance Imaging - methods ; Male ; Middle Aged ; N-Acetyl aspartate ; Negative symptoms ; Neurology ; Pessimism ; Prefrontal Cortex - metabolism ; Randomized controlled trial ; Schizophrenia ; Schizophrenia - diagnostic imaging ; Schizophrenia - metabolism ; Schizophrenia - therapy ; Transcranial magnetic stimulation ; Transcranial Magnetic Stimulation - methods ; Treatment Outcome ; Young Adult</subject><ispartof>Brain stimulation, 2017-01, Vol.10 (1), p.59-64</ispartof><rights>Elsevier Inc.</rights><rights>2016 Elsevier Inc.</rights><rights>Copyright © 2016 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-f4132a4a51d555a793c03c8bf2d2324a9124468540a5a5c48e08ce4729f488d83</citedby><cites>FETCH-LOGICAL-c451t-f4132a4a51d555a793c03c8bf2d2324a9124468540a5a5c48e08ce4729f488d83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27615793$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dlabac-de Lange, Jozarni J., MD, PhD</creatorcontrib><creatorcontrib>Liemburg, Edith J., PhD</creatorcontrib><creatorcontrib>Bais, Leonie, MSc</creatorcontrib><creatorcontrib>van de Poel-Mustafayeva, Aida T</creatorcontrib><creatorcontrib>de Lange-de Klerk, E.S.M., MD, PhD</creatorcontrib><creatorcontrib>Knegtering, Henderikus, MD, PhD</creatorcontrib><creatorcontrib>Aleman, André, PhD</creatorcontrib><title>Effect of Bilateral Prefrontal rTMS on Left Prefrontal NAA and Glx Levels in Schizophrenia Patients with Predominant Negative Symptoms: an Exploratory Study</title><title>Brain stimulation</title><addtitle>Brain Stimul</addtitle><description>Highlights • We studied neurotransmitters concentrations changes in the left prefrontal cortex of patients with schizophrenia after bilateral prefrontal high frequency rTMS • An increase of glutamate concentration was found after active rTMS, a decrease after sham rTMS • Prefrontal rTMS did not influence N-Acetyl Aspartate concentration • High frequency prefrontal rTMS may increase prefrontal metabolism in patients with schizophrenia</description><subject>1H-Magnetic resonance spectroscopy</subject><subject>Adult</subject><subject>Aspartic Acid - analogs & derivatives</subject><subject>Aspartic Acid - metabolism</subject><subject>Dorsolateral prefrontal cortex</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Glutamate</subject><subject>Glutamic Acid - metabolism</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>N-Acetyl aspartate</subject><subject>Negative symptoms</subject><subject>Neurology</subject><subject>Pessimism</subject><subject>Prefrontal Cortex - metabolism</subject><subject>Randomized controlled trial</subject><subject>Schizophrenia</subject><subject>Schizophrenia - diagnostic imaging</subject><subject>Schizophrenia - metabolism</subject><subject>Schizophrenia - therapy</subject><subject>Transcranial magnetic stimulation</subject><subject>Transcranial Magnetic Stimulation - methods</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>1935-861X</issn><issn>1876-4754</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp9UsFuEzEUXCEQLYUP4IJ85LKL7bV3vSAhhSotSKFUSpG4WY73LXHw2sF2QrffwsfiKAUhDpw88psZ6c28onhOcEUwaV5tqlWIFc2wwqLCmD4oTolom5K1nD3MuKt5KRry5aR4EuMGY951on1cnNC2Ibzt6tPi53wYQCfkB_TOWJUgKIuuAwzBu5RhuPm4RN6hBQzp7_-r2Qwp16NLe5tne7ARGYeWem3u_HYdwBmFrlUy4FJEP0xaH8S9H41TLqEr-Jpne0DLadwmP8bX2QzNb7fWB5V8mNAy7frpafFoUDbCs_v3rPh8Mb85f18uPl1-OJ8tSs04SeXASE0VU5z0nHOV99K41mI10J7WlKmOUMYawRlWXHHNBGChgbW0G5gQvajPipdH323w33cQkxxN1GCtcuB3URLBu5ZmbpOp5EjVwceY85DbYEYVJkmwPJQiNzKXIg-lSCxkLiVrXtzb71Yj9H8Uv1vIhDdHQo4R9gaCjDonp6E3IZcje2_-a__2H7W2xhmt7DeYIG78LricniQyUonl8nAVh6MgTY0p5qz-BeWUsyU</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Dlabac-de Lange, Jozarni J., MD, PhD</creator><creator>Liemburg, Edith J., PhD</creator><creator>Bais, Leonie, MSc</creator><creator>van de Poel-Mustafayeva, Aida T</creator><creator>de Lange-de Klerk, E.S.M., MD, PhD</creator><creator>Knegtering, Henderikus, MD, PhD</creator><creator>Aleman, André, PhD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170101</creationdate><title>Effect of Bilateral Prefrontal rTMS on Left Prefrontal NAA and Glx Levels in Schizophrenia Patients with Predominant Negative Symptoms: an Exploratory Study</title><author>Dlabac-de Lange, Jozarni J., MD, PhD ; Liemburg, Edith J., PhD ; Bais, Leonie, MSc ; van de Poel-Mustafayeva, Aida T ; de Lange-de Klerk, E.S.M., MD, PhD ; Knegtering, Henderikus, MD, PhD ; Aleman, André, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-f4132a4a51d555a793c03c8bf2d2324a9124468540a5a5c48e08ce4729f488d83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>1H-Magnetic resonance spectroscopy</topic><topic>Adult</topic><topic>Aspartic Acid - analogs & derivatives</topic><topic>Aspartic Acid - metabolism</topic><topic>Dorsolateral prefrontal cortex</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Glutamate</topic><topic>Glutamic Acid - metabolism</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>N-Acetyl aspartate</topic><topic>Negative symptoms</topic><topic>Neurology</topic><topic>Pessimism</topic><topic>Prefrontal Cortex - metabolism</topic><topic>Randomized controlled trial</topic><topic>Schizophrenia</topic><topic>Schizophrenia - diagnostic imaging</topic><topic>Schizophrenia - metabolism</topic><topic>Schizophrenia - therapy</topic><topic>Transcranial magnetic stimulation</topic><topic>Transcranial Magnetic Stimulation - methods</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dlabac-de Lange, Jozarni J., MD, PhD</creatorcontrib><creatorcontrib>Liemburg, Edith J., PhD</creatorcontrib><creatorcontrib>Bais, Leonie, MSc</creatorcontrib><creatorcontrib>van de Poel-Mustafayeva, Aida T</creatorcontrib><creatorcontrib>de Lange-de Klerk, E.S.M., MD, PhD</creatorcontrib><creatorcontrib>Knegtering, Henderikus, MD, PhD</creatorcontrib><creatorcontrib>Aleman, André, PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Brain stimulation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dlabac-de Lange, Jozarni J., MD, PhD</au><au>Liemburg, Edith J., PhD</au><au>Bais, Leonie, MSc</au><au>van de Poel-Mustafayeva, Aida T</au><au>de Lange-de Klerk, E.S.M., MD, PhD</au><au>Knegtering, Henderikus, MD, PhD</au><au>Aleman, André, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Bilateral Prefrontal rTMS on Left Prefrontal NAA and Glx Levels in Schizophrenia Patients with Predominant Negative Symptoms: an Exploratory Study</atitle><jtitle>Brain stimulation</jtitle><addtitle>Brain Stimul</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>10</volume><issue>1</issue><spage>59</spage><epage>64</epage><pages>59-64</pages><issn>1935-861X</issn><eissn>1876-4754</eissn><abstract>Highlights • We studied neurotransmitters concentrations changes in the left prefrontal cortex of patients with schizophrenia after bilateral prefrontal high frequency rTMS • An increase of glutamate concentration was found after active rTMS, a decrease after sham rTMS • Prefrontal rTMS did not influence N-Acetyl Aspartate concentration • High frequency prefrontal rTMS may increase prefrontal metabolism in patients with schizophrenia</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>27615793</pmid><doi>10.1016/j.brs.2016.08.002</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1935-861X |
| ispartof | Brain stimulation, 2017-01, Vol.10 (1), p.59-64 |
| issn | 1935-861X 1876-4754 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1859724886 |
| source | ScienceDirect Journals |
| subjects | 1H-Magnetic resonance spectroscopy Adult Aspartic Acid - analogs & derivatives Aspartic Acid - metabolism Dorsolateral prefrontal cortex Double-Blind Method Female Glutamate Glutamic Acid - metabolism Humans Magnetic Resonance Imaging - methods Male Middle Aged N-Acetyl aspartate Negative symptoms Neurology Pessimism Prefrontal Cortex - metabolism Randomized controlled trial Schizophrenia Schizophrenia - diagnostic imaging Schizophrenia - metabolism Schizophrenia - therapy Transcranial magnetic stimulation Transcranial Magnetic Stimulation - methods Treatment Outcome Young Adult |
| title | Effect of Bilateral Prefrontal rTMS on Left Prefrontal NAA and Glx Levels in Schizophrenia Patients with Predominant Negative Symptoms: an Exploratory Study |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T07%3A03%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20Bilateral%20Prefrontal%20rTMS%20on%20Left%20Prefrontal%20NAA%20and%20Glx%20Levels%20in%20Schizophrenia%20Patients%20with%20Predominant%20Negative%20Symptoms:%20an%20Exploratory%20Study&rft.jtitle=Brain%20stimulation&rft.au=Dlabac-de%20Lange,%20Jozarni%20J.,%20MD,%20PhD&rft.date=2017-01-01&rft.volume=10&rft.issue=1&rft.spage=59&rft.epage=64&rft.pages=59-64&rft.issn=1935-861X&rft.eissn=1876-4754&rft_id=info:doi/10.1016/j.brs.2016.08.002&rft_dat=%3Cproquest_cross%3E1859724886%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c451t-f4132a4a51d555a793c03c8bf2d2324a9124468540a5a5c48e08ce4729f488d83%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1859724886&rft_id=info:pmid/27615793&rfr_iscdi=true |