Review of flavonoids: A diverse group of natural compounds with anti- Candida albicans activity in vitro

Highlights • Flavonoids are a subdivision of polyphenols, a versatile class of natural compounds that represent secondary metabolites from higher plants with several reported protective activities, such as antifungal. • Subclasses of flavonoids include: chalcones, flavones, isoflavones, flavanols, f...

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Bibliographic Details
Published in:Archives of oral biology 2017-04, Vol.76, p.76-83
Main Authors: Seleem, Dalia, Pardi, Vanessa, Murata, Ramiro Mendonça
Format: Article
Language:English
Subjects:
Advanced Basic Science
Antifungal activity
Antifungal Agents - pharmacology
Apoptosis - drug effects
Candida albicans - drug effects
Candidiasis, Oral - drug therapy
Cell Wall - drug effects
Dentistry
Drug resistance
Drug Resistance, Fungal
Flavonoids
Flavonoids - pharmacology
In Vitro Techniques
Microbial Sensitivity Tests
Oral candidiasis
Polyphenols
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Summary:Highlights • Flavonoids are a subdivision of polyphenols, a versatile class of natural compounds that represent secondary metabolites from higher plants with several reported protective activities, such as antifungal. • Subclasses of flavonoids include: chalcones, flavones, isoflavones, flavanols, flavanones, flavonols, and anthocyanidins. • The antifungal activity of flavonoids against C. albicans in vitro were reported in the literature, among potent compounds were quercetin and myricetin (flavonols), baicalein (flavones), catechins (flavanols), and carvacrol (chalcones). • Mechanisms of action for antifungal effects of flavonoids included inhibition of efflux pump and induction of apoptosis (baicalein and sedonan A), cell wall damage (catechins), and cytoplasmic membrane disruption (carvacrol). • Plasma membrane transporters play a critical role in binding of flavonoids to plasma membrane and hence determine the bioavailability of flavonoids, applied as xenobiotics.
ISSN:0003-9969
1879-1506
DOI:10.1016/j.archoralbio.2016.08.030