The effect of CPAP treatment on venous lactate and arterial blood gas among obstructive sleep apnea syndrome patients

• Published in: Sleep & breathing 2017-05, Vol.21 (2), p.303-309
• Main Authors: Lin, Ting, Huang, Jie-Feng, Lin, Qi-Chang, Chen, Gong-Ping, Wang, Bi-Ying, Zhao, Jian-Ming, Qi, Jia-Chao
• Format: Article
• Language: English
• Subjects: Adult; Blood Gas Analysis; China; Continuous Positive Airway Pressure; Dentistry; Female; Humans; Internal Medicine; Lactic Acid - blood; Male; Medicine; Medicine & Public Health; Middle Aged; Neurology; Otorhinolaryngology; Patients; Pediatrics; Pneumology/Respiratory System; Risk Factors; Sleep apnea; Sleep Apnea, Obstructive - blood; Sleep Apnea, Obstructive - therapy; Sleep Breathing Physiology and Disorders • Original Article; Therapy; Veins & arteries
• ISSN: 1520-9512; 1522-1709
• DOI: 10.1007/s11325-016-1409-x

Purpose The aim of this observational study was to investigate the influence of continuous positive airway pressure (CPAP) on arterial blood gas and venous lactate, markers of tissue hypoxia, among obstructive sleep apnea syndrome (OSAS) patients, and determine the risk factor of serum lactate and hydrogen ion concentration (PH) in OSAS patients. Materials and methods One-hundred and nine patients with newly diagnosed OSAS were enrolled in the study. All individuals were treated with CPAP for one night. Venous lactate and arterial blood gas were gathered from all subjects in the morning at the end of polysomnography and the next morning after CPAP treatment. Results Of the 109 selected subjects, the average lactate level was 2.23 ± 0.59 mmol/L, and the mean PH, PaO 2 , and PaCO 2 were 7.380 ± 0.23, 88.14 ± 17.83 mmHg, and 38.70 ± 4.28 mmHg, respectively. Compared to baseline, lactic acid significantly decreased (2.10 ± 0.50 mmol/L, p  = 0.03), while PH increased (7.388 ± 0.27, p