Pestalotic acids A-I, antibacterial ambuic acid analogues, from a mycoparasite (Pestalotipsis sp. cr014) of Cronartium ribicola

The white pine blister rust caused by Cronartium ribicola is a severe disease of Pinus armandii Franch in Sichuan Province, China. A mycoparasite was isolated from aeciospore piles of C. ribicola and identified as Pestalotipsis sp. The chemical constituents were investigated and nine new polyketides...

Full description

Saved in:
Bibliographic Details
Published in:Archives of pharmacal research 2016-09
Main Authors: Li, Jing, Xie, Jin, Yu, Fei-Xue, Chen, Yu-Hui, Zhao, Pei-Ji
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The white pine blister rust caused by Cronartium ribicola is a severe disease of Pinus armandii Franch in Sichuan Province, China. A mycoparasite was isolated from aeciospore piles of C. ribicola and identified as Pestalotipsis sp. The chemical constituents were investigated and nine new polyketides, named pestalotic acids A-I (1-9), were isolated from solid fermentation products of Pestalotiopsis sp. cr014. Their structures were elucidated by extensive spectroscopic methods, including 1D- and 2D- NMR, HR-MS experiments. Compounds 2-5 and 7-9 exhibited strong antibacterial activities in vitro against five plant pathogens, with minimum inhibitory concentration values of 0.78-100 µg/mL.
ISSN:0253-6269
1976-3786
DOI:10.1007/s12272-016-0837-2