Influence of stenosis on hemodynamic parameters in the realistic left coronary artery under hyperemic conditions

• Published in: Computer methods in biomechanics and biomedical engineering 2017-03, Vol.20 (4), p.365-372
• Main Authors: Kamangar, Sarfaraz, Badruddin, Irfan Anjum, Badarudin, A., Nik-Ghazali, N., Govindaraju, Kalimuthu, Salman Ahmed, N. J., Yunus Khan, T. M.
• Format: Article
• Language: English
• Subjects: Blood Flow Velocity; Cardiovascular disease; CFD; Computational fluid dynamics; Computed tomography; Computer applications; Computer simulation; Constriction, Pathologic - physiopathology; Coronary artery; Coronary artery disease; Coronary Circulation; Coronary Stenosis - diagnostic imaging; Coronary Stenosis - physiopathology; Coronary vessels; Coronary Vessels - diagnostic imaging; Coronary Vessels - physiopathology; Downstream; Fluid dynamics; Heart diseases; Hemodynamics; Humans; Hydrodynamics; Hyperemia - diagnostic imaging; Hyperemia - physiopathology; Imaging, Three-Dimensional; Mathematical models; Mechanical stimuli; Models, Cardiovascular; non-Newtonian flow; Patients; Pressure; Pressure drop; Reconstruction; Shear stress; Stenosis; Stress concentration; Stress, Mechanical; Three dimensional models; Tomography, X-Ray Computed; Velocity
• ISSN: 1025-5842; 1476-8259
• DOI: 10.1080/10255842.2016.1233402

The current study investigates the hyperemic flow effects on heamodynamics parameters such as velocity, wall shear stress in 3D coronary artery models with and without stenosis. The hyperemic flow is used to evaluate the functional significance of stenosis in the current era. Patients CT scan data of having healthy and coronary artery disease was chosen for the reconstruction of 3D coronary artery models. The diseased 3D models of coronary artery shows a narrowing of >50% lumen area. Computational fluid dynamics was performed to simulate the hyperemic flow condition. The results showed that the recirculation zone was observed immediate to the stenosis and highest wall shear stress was observed across the stenosis. The decrease in pressure was found downstream to the stenosis as compared to the coronary artery without stenosis. Our analysis provides an insight into the distribution of wall shear stress and pressure drop, thus improving our understanding of hyperemic flow effect under both conditions.