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Is body mass index relevant to prognosis of papillary thyroid carcinoma? A clinicopathological cohort study
Purpose Obesity appears to be related to papillary thyroid carcinoma (PTC) in the observational studies, although its relationship concerning the PTC prognosis has not been established. We investigated the association between body mass index (BMI) and the prognosis of PTC. Methods The WHO BMI classi...
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| Published in: | Surgery today (Tokyo, Japan) Japan), 2017-04, Vol.47 (4), p.506-512 |
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| cites | cdi_FETCH-LOGICAL-c368t-9cd3befc1ba33373d23664fd48f03004a31d59fb5c350e4202979f39dc1b01993 |
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| container_title | Surgery today (Tokyo, Japan) |
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| creator | Chung, Yoo Seung Lee, Joon-Hyop Lee, Young Don |
| description | Purpose
Obesity appears to be related to papillary thyroid carcinoma (PTC) in the observational studies, although its relationship concerning the PTC prognosis has not been established. We investigated the association between body mass index (BMI) and the prognosis of PTC.
Methods
The WHO BMI classification was used to stratify the degree of obesity. The final outcome was disease status, including recurrence and persistence, of 783 PTC patients. We reviewed patients’ BMI, disease status, and other prognostic factors retrospectively.
Results
The mean BMI was 24.2 kg/m
2
. When stratified according to the WHO BMI classification, 21 were Underweight, 482 were Normal, 232 were Overweight, and 48 were Obese. We divided patients into two groups: |
| doi_str_mv | 10.1007/s00595-016-1417-2 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1859737416</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1859737416</sourcerecordid><originalsourceid>FETCH-LOGICAL-c368t-9cd3befc1ba33373d23664fd48f03004a31d59fb5c350e4202979f39dc1b01993</originalsourceid><addsrcrecordid>eNp9kDtv3DAQhAkjhu_8-AFuApZplOyS1INVcDjEzgEG3Ng1QZHUHW1JVEgpyP370DgnpastdmYw8xFyi_AVAepvCaCUZQFYFSiwLtgZWaPgVcEa5J_IGqTAApnEFblM6QWAiQbggqxYXZVClHxNXneJtsEe6aBTon607g-Nrne_9TjTOdAphv0Ykk80dHTSk-97HY90Phxj8JYaHY0fw6C_0w01vR-9CZOeD6EPe290T004hDjTNC_2eE3OO90nd_N-r8jz3Y-n7c_i4fF-t908FIZXzVxIY3nrOoOt5pzX3DJeVaKzoumAAwjN0Zaya0vDS3CCAZO17Li02QEoJb8iX065ufyvxaVZDT4Zl5uPLixJYVPKmtcCqyzFk9TEkFJ0nZqiH_JChaDeGKsTY5UZqzfGimXP5_f4pR2c_e_4BzUL2EmQ8mvcu6hewhLHPPmD1L-FnIgl</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1859737416</pqid></control><display><type>article</type><title>Is body mass index relevant to prognosis of papillary thyroid carcinoma? A clinicopathological cohort study</title><source>Springer Nature</source><creator>Chung, Yoo Seung ; Lee, Joon-Hyop ; Lee, Young Don</creator><creatorcontrib>Chung, Yoo Seung ; Lee, Joon-Hyop ; Lee, Young Don</creatorcontrib><description>Purpose
Obesity appears to be related to papillary thyroid carcinoma (PTC) in the observational studies, although its relationship concerning the PTC prognosis has not been established. We investigated the association between body mass index (BMI) and the prognosis of PTC.
Methods
The WHO BMI classification was used to stratify the degree of obesity. The final outcome was disease status, including recurrence and persistence, of 783 PTC patients. We reviewed patients’ BMI, disease status, and other prognostic factors retrospectively.
Results
The mean BMI was 24.2 kg/m
2
. When stratified according to the WHO BMI classification, 21 were Underweight, 482 were Normal, 232 were Overweight, and 48 were Obese. We divided patients into two groups: <25.0 kg/m
2
(
n
= 503) vs. ≥25.0 kg/m
2
(
n
= 280). The BMI ≥25.0 group was older and more likely to be male in a multivariate analysis (
p
< 0.001). For those with BMI <25.0 and ≥25.0, recurrence occurred in 3.0 and 2.1 % (
p
= 0.486), persistence in 7.2 and 5.1 % (
p
= 0.265), and either recurrence or persistence in 9.9 and 7.1 %, respectively (
p
= 0.189). A multivariate analysis revealed that older age and male gender in Overweight vs. Normal, older age in Obese vs. Normal, and advanced T stage in Normal vs. Underweight were statistically significant prognostic factors.
Conclusions
There was no significant difference in the prognosis according to BMI in PTC patients. However, old age, male gender, and advanced T-stage patients were found more frequently in the higher BMI group than in the lower BMI group.</description><identifier>ISSN: 0941-1291</identifier><identifier>EISSN: 1436-2813</identifier><identifier>DOI: 10.1007/s00595-016-1417-2</identifier><identifier>PMID: 27654453</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Adult ; Age Factors ; Body Mass Index ; Carcinoma - pathology ; Carcinoma, Papillary ; Cohort Studies ; Female ; Humans ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Multivariate Analysis ; Neoplasm Staging ; Obesity ; Original Article ; Prognosis ; Sex Factors ; Surgery ; Surgical Oncology ; Thyroid Cancer, Papillary ; Thyroid Neoplasms - pathology</subject><ispartof>Surgery today (Tokyo, Japan), 2017-04, Vol.47 (4), p.506-512</ispartof><rights>Springer Japan 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-9cd3befc1ba33373d23664fd48f03004a31d59fb5c350e4202979f39dc1b01993</citedby><cites>FETCH-LOGICAL-c368t-9cd3befc1ba33373d23664fd48f03004a31d59fb5c350e4202979f39dc1b01993</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27654453$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chung, Yoo Seung</creatorcontrib><creatorcontrib>Lee, Joon-Hyop</creatorcontrib><creatorcontrib>Lee, Young Don</creatorcontrib><title>Is body mass index relevant to prognosis of papillary thyroid carcinoma? A clinicopathological cohort study</title><title>Surgery today (Tokyo, Japan)</title><addtitle>Surg Today</addtitle><addtitle>Surg Today</addtitle><description>Purpose
Obesity appears to be related to papillary thyroid carcinoma (PTC) in the observational studies, although its relationship concerning the PTC prognosis has not been established. We investigated the association between body mass index (BMI) and the prognosis of PTC.
Methods
The WHO BMI classification was used to stratify the degree of obesity. The final outcome was disease status, including recurrence and persistence, of 783 PTC patients. We reviewed patients’ BMI, disease status, and other prognostic factors retrospectively.
Results
The mean BMI was 24.2 kg/m
2
. When stratified according to the WHO BMI classification, 21 were Underweight, 482 were Normal, 232 were Overweight, and 48 were Obese. We divided patients into two groups: <25.0 kg/m
2
(
n
= 503) vs. ≥25.0 kg/m
2
(
n
= 280). The BMI ≥25.0 group was older and more likely to be male in a multivariate analysis (
p
< 0.001). For those with BMI <25.0 and ≥25.0, recurrence occurred in 3.0 and 2.1 % (
p
= 0.486), persistence in 7.2 and 5.1 % (
p
= 0.265), and either recurrence or persistence in 9.9 and 7.1 %, respectively (
p
= 0.189). A multivariate analysis revealed that older age and male gender in Overweight vs. Normal, older age in Obese vs. Normal, and advanced T stage in Normal vs. Underweight were statistically significant prognostic factors.
Conclusions
There was no significant difference in the prognosis according to BMI in PTC patients. However, old age, male gender, and advanced T-stage patients were found more frequently in the higher BMI group than in the lower BMI group.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Body Mass Index</subject><subject>Carcinoma - pathology</subject><subject>Carcinoma, Papillary</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Neoplasm Staging</subject><subject>Obesity</subject><subject>Original Article</subject><subject>Prognosis</subject><subject>Sex Factors</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Thyroid Cancer, Papillary</subject><subject>Thyroid Neoplasms - pathology</subject><issn>0941-1291</issn><issn>1436-2813</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp9kDtv3DAQhAkjhu_8-AFuApZplOyS1INVcDjEzgEG3Ng1QZHUHW1JVEgpyP370DgnpastdmYw8xFyi_AVAepvCaCUZQFYFSiwLtgZWaPgVcEa5J_IGqTAApnEFblM6QWAiQbggqxYXZVClHxNXneJtsEe6aBTon607g-Nrne_9TjTOdAphv0Ykk80dHTSk-97HY90Phxj8JYaHY0fw6C_0w01vR-9CZOeD6EPe290T004hDjTNC_2eE3OO90nd_N-r8jz3Y-n7c_i4fF-t908FIZXzVxIY3nrOoOt5pzX3DJeVaKzoumAAwjN0Zaya0vDS3CCAZO17Li02QEoJb8iX065ufyvxaVZDT4Zl5uPLixJYVPKmtcCqyzFk9TEkFJ0nZqiH_JChaDeGKsTY5UZqzfGimXP5_f4pR2c_e_4BzUL2EmQ8mvcu6hewhLHPPmD1L-FnIgl</recordid><startdate>20170401</startdate><enddate>20170401</enddate><creator>Chung, Yoo Seung</creator><creator>Lee, Joon-Hyop</creator><creator>Lee, Young Don</creator><general>Springer Japan</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170401</creationdate><title>Is body mass index relevant to prognosis of papillary thyroid carcinoma? A clinicopathological cohort study</title><author>Chung, Yoo Seung ; Lee, Joon-Hyop ; Lee, Young Don</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-9cd3befc1ba33373d23664fd48f03004a31d59fb5c350e4202979f39dc1b01993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Body Mass Index</topic><topic>Carcinoma - pathology</topic><topic>Carcinoma, Papillary</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Neoplasm Staging</topic><topic>Obesity</topic><topic>Original Article</topic><topic>Prognosis</topic><topic>Sex Factors</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Thyroid Cancer, Papillary</topic><topic>Thyroid Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chung, Yoo Seung</creatorcontrib><creatorcontrib>Lee, Joon-Hyop</creatorcontrib><creatorcontrib>Lee, Young Don</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Surgery today (Tokyo, Japan)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chung, Yoo Seung</au><au>Lee, Joon-Hyop</au><au>Lee, Young Don</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Is body mass index relevant to prognosis of papillary thyroid carcinoma? A clinicopathological cohort study</atitle><jtitle>Surgery today (Tokyo, Japan)</jtitle><stitle>Surg Today</stitle><addtitle>Surg Today</addtitle><date>2017-04-01</date><risdate>2017</risdate><volume>47</volume><issue>4</issue><spage>506</spage><epage>512</epage><pages>506-512</pages><issn>0941-1291</issn><eissn>1436-2813</eissn><abstract>Purpose
Obesity appears to be related to papillary thyroid carcinoma (PTC) in the observational studies, although its relationship concerning the PTC prognosis has not been established. We investigated the association between body mass index (BMI) and the prognosis of PTC.
Methods
The WHO BMI classification was used to stratify the degree of obesity. The final outcome was disease status, including recurrence and persistence, of 783 PTC patients. We reviewed patients’ BMI, disease status, and other prognostic factors retrospectively.
Results
The mean BMI was 24.2 kg/m
2
. When stratified according to the WHO BMI classification, 21 were Underweight, 482 were Normal, 232 were Overweight, and 48 were Obese. We divided patients into two groups: <25.0 kg/m
2
(
n
= 503) vs. ≥25.0 kg/m
2
(
n
= 280). The BMI ≥25.0 group was older and more likely to be male in a multivariate analysis (
p
< 0.001). For those with BMI <25.0 and ≥25.0, recurrence occurred in 3.0 and 2.1 % (
p
= 0.486), persistence in 7.2 and 5.1 % (
p
= 0.265), and either recurrence or persistence in 9.9 and 7.1 %, respectively (
p
= 0.189). A multivariate analysis revealed that older age and male gender in Overweight vs. Normal, older age in Obese vs. Normal, and advanced T stage in Normal vs. Underweight were statistically significant prognostic factors.
Conclusions
There was no significant difference in the prognosis according to BMI in PTC patients. However, old age, male gender, and advanced T-stage patients were found more frequently in the higher BMI group than in the lower BMI group.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>27654453</pmid><doi>10.1007/s00595-016-1417-2</doi><tpages>7</tpages></addata></record> |
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| ispartof | Surgery today (Tokyo, Japan), 2017-04, Vol.47 (4), p.506-512 |
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| language | eng |
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| source | Springer Nature |
| subjects | Adult Age Factors Body Mass Index Carcinoma - pathology Carcinoma, Papillary Cohort Studies Female Humans Male Medicine Medicine & Public Health Middle Aged Multivariate Analysis Neoplasm Staging Obesity Original Article Prognosis Sex Factors Surgery Surgical Oncology Thyroid Cancer, Papillary Thyroid Neoplasms - pathology |
| title | Is body mass index relevant to prognosis of papillary thyroid carcinoma? A clinicopathological cohort study |
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