Usefulness of urinary glucose excretion after oral glucose tolerance testing to detect insulin secretion failure before the onset of diabetes mellitus

• Published in: ENDOCRINE JOURNAL 2017, Vol.64(1), pp.75-81
• Main Authors: Ono, Yosuke, Ono, Sachiko, Hinata, Takashi, Ito, Toshimitsu, Yasuda, Hiroko, Tanaka, Yuji
• Format: Article
• Language: English
• Subjects: Adult; Cross-Sectional Studies; Female; Glucose - analysis; Glucose Tolerance Test; Glycosuria - diagnosis; Glycosuria - urine; Humans; Impaired glucose tolerance; Insulin - metabolism; Insulin Secretion; Insulinogenic index; Male; Middle Aged; Prediabetes; Prediabetic State - blood; Prediabetic State - diagnosis; Prediabetic State - urine; Predictive Value of Tests; Retrospective Studies; Sodium-glucose cotransporter 2 inhibitors; Urinalysis; Urinary glucose excretion
• ISSN: 0918-8959; 1348-4540
• DOI: 10.1507/endocrj.EJ16-0289

Sodium-glucose cotransporter 2 inhibitors are commonly used to promote urinary glucose excretion (UGE). However, it remains unclear how UGE reflects glucose metabolism in the natural history of diabetes. Thus, we retrospectively reviewed the prediabetes medical records of 64 patients who had undergone 75-g oral glucose tolerance testing (OGTT) with measurements of UGE at 0 min, 60 min, and 120 min. The mean age and glycated hemoglobin levels were 46 ± 10 years and 5.6 ± 0.3%, respectively. The median UGE (60 min + 120 min) value was 16.8 mg ([interquartile range]: [10.5-150.0 mg]). Thus, we categorized 16 patients as having high UGE (≥150.0 mg) and 48 patients as having low UGE (