Dual energy CT allows for improved characterization of response to antiangiogenic treatment in patients with metastatic renal cell cancer

Objectives To evaluate the potential role of dual energy CT (DECT) to visualize antiangiogenic treatment effects in patients with metastatic renal cell cancer (mRCC) while treated with tyrosine-kinase inhibitors (TKI). Methods 26 patients with mRCC underwent baseline and follow-up single-phase abdom...

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Bibliographic Details
Published in:European radiology 2017-06, Vol.27 (6), p.2532-2537
Main Authors: Hellbach, K., Sterzik, A., Sommer, W., Karpitschka, M., Hummel, N., Casuscelli, J., Ingrisch, M., Schlemmer, M., Graser, A., Staehler, Michael
Format: Article
Language:English
Subjects:
Abdomen
Aged
Angiogenesis Inhibitors - therapeutic use
Carcinoma, Renal Cell - diagnostic imaging
Carcinoma, Renal Cell - drug therapy
Contrast agents
Contrast Media - metabolism
Diagnostic Radiology
Energy
Female
Humans
Imaging
Indoles - therapeutic use
Internal Medicine
Interventional Radiology
Iodine
Iodine - metabolism
Kidney cancer
Kidney Neoplasms - diagnostic imaging
Kidney Neoplasms - drug therapy
Male
Medicine
Medicine & Public Health
Metastasis
Middle Aged
Neoplasm Metastasis
Neuroradiology
Oncology
Prospective Studies
Protein-Tyrosine Kinases - antagonists & inhibitors
Pyrroles - therapeutic use
Radiology
Sunitinib
Tomography
Tomography, X-Ray Computed - methods
Treatment Outcome
Tumors
Ultrasound
Vascular endothelial growth factor
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Summary:Objectives To evaluate the potential role of dual energy CT (DECT) to visualize antiangiogenic treatment effects in patients with metastatic renal cell cancer (mRCC) while treated with tyrosine-kinase inhibitors (TKI). Methods 26 patients with mRCC underwent baseline and follow-up single-phase abdominal contrast enhanced DECT scans. Scans were performed immediately before and 10 weeks after start of treatment with TKI. Virtual non-enhanced (VNE) and colour coded iodine images were generated. 44 metastases were measured at the two time points. Hounsfield unit (HU) values for VNE and iodine density (ID) as well as iodine content (IC) in mg/ml of tissue were derived. These values were compared to the venous phase DECT density (CTD) of the lesions. Values before and after treatment were compared using a paired Student’s t test. Results Between baseline and follow up, mean CTD and DECT-derived ID both showed a significant reduction (p 
ISSN:0938-7994
1432-1084
DOI:10.1007/s00330-016-4597-7