Effects of novel oral anticoagulants on left atrial and left atrial appendage thrombi: an appraisal

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and predisposes to an increased risk of thromboembolic events. Patients affected by AF exhibit an increased risk of stroke compared with those in sinus rhythm, with the most common location of thrombi in the left atrial appenda...

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Bibliographic Details
Published in:Journal of thrombosis and thrombolysis 2017-02, Vol.43 (2), p.139-148
Main Authors: Marsico, Fabio, Cecere, Milena, Parente, Antonio, Paolillo, Stefania, de Martino, Fabiana, Dellegrottaglie, Santo, Trimarco, Bruno, Perrone Filardi, Pasquale
Format: Article
Language:English
Subjects:
Administration, Oral
Anticoagulants - therapeutic use
Atrial Appendage - pathology
Atrial Fibrillation - complications
Cardiology
Heart Atria - pathology
Hematology
Humans
Medicine
Medicine & Public Health
Stroke - prevention & control
Thrombosis - drug therapy
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Summary:Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and predisposes to an increased risk of thromboembolic events. Patients affected by AF exhibit an increased risk of stroke compared with those in sinus rhythm, with the most common location of thrombi in the left atrial appendage. Until 2009, warfarin and other vitamin K antagonists were the only class of oral anticoagulants available. More recently, dabigatran, rivaroxaban, apixaban, and edoxaban have been approved by regulatory authorities for prevention of stroke in patients with non-valvular AF. Few data are available about the efficacy of novel oral anticoagulants for the treatment of left atrial and left atrial appendage thrombosis. Aim of this review is to summarize available evidence regarding the effectiveness of novel oral anticoagulants on left atrial appendage thrombosis.
ISSN:0929-5305
1573-742X
DOI:10.1007/s11239-016-1421-9