Bioavailability of voriconazole in hospitalised patients

Highlights • Switch from intravenous to oral antimicrobial therapy is suggested if clinically justified. • Correct judgement of voriconazole levels is difficult due to its complicated pharmacokinetics. • Reduced voriconazole levels during oral treatment may be caused by factors other than bioavailab...

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Bibliographic Details
Published in:International journal of antimicrobial agents 2017-02, Vol.49 (2), p.243-246
Main Authors: Veringa, Anette, Geling, Sanne, Span, Lambert F.R, Vermeulen, Karin M, Zijlstra, Jan G, van der Werf, Tjip S, Kosterink, Jos G.W, Alffenaar, Jan-Willem C
Format: Article
Language:English
Subjects:
Administration, Intravenous
Administration, Oral
Adolescent
Adult
Aged
Aged, 80 and over
Antifungal Agents - administration & dosage
Antifungal Agents - pharmacokinetics
Antifungal stewardship
Bioavailability
Biological Availability
Drug Monitoring
Female
Humans
Infectious Disease
Male
Middle Aged
Pharmacokinetics
Retrospective Studies
Serum - chemistry
Therapeutic drug monitoring
Time Factors
Voriconazole
Voriconazole - administration & dosage
Voriconazole - pharmacokinetics
Young Adult
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Summary:Highlights • Switch from intravenous to oral antimicrobial therapy is suggested if clinically justified. • Correct judgement of voriconazole levels is difficult due to its complicated pharmacokinetics. • Reduced voriconazole levels during oral treatment may be caused by factors other than bioavailability. • Voriconazole treatment should be guided by an antifungal stewardship team.
ISSN:0924-8579
1872-7913
DOI:10.1016/j.ijantimicag.2016.10.010