Changes of in vitro potency of anticoagulant drugs are similar between patients with cirrhosis due to alcohol or non-alcoholic fatty liver disease

Highlights • The in vitro anticoagulant potency of commonly used anticoagulants is substantially different in plasma from patients with cirrhosis compared to healthy individuals • The hemostatic changes in patients with cirrhosis of different etiologies are similar but not identical • In comparing t...

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Bibliographic Details
Published in:Thrombosis research 2017-02, Vol.150, p.41-43
Main Authors: Bos, Sarah, Potze, Wilma, Siddiqui, Mohammad S, Boyett, Sherry L, Adelmeijer, Jelle, Daita, Kalyani, Lisman, Ton, Sanyal, Arun J
Format: Article
Language:English
Subjects:
Adult
Alcoholism - blood
Alcoholism - complications
Anticoagulants - pharmacology
Anticoagulants - therapeutic use
Dabigatran - pharmacology
Dabigatran - therapeutic use
Enoxaparin - pharmacology
Enoxaparin - therapeutic use
Female
Hematology, Oncology and Palliative Medicine
Hemostasis - drug effects
Humans
Liver Cirrhosis - blood
Liver Cirrhosis - complications
Liver Cirrhosis - etiology
Male
Middle Aged
Non-alcoholic Fatty Liver Disease - blood
Non-alcoholic Fatty Liver Disease - complications
Pyrazoles - pharmacology
Pyrazoles - therapeutic use
Pyridones - pharmacology
Pyridones - therapeutic use
Thrombosis - etiology
Thrombosis - prevention & control
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Summary:Highlights • The in vitro anticoagulant potency of commonly used anticoagulants is substantially different in plasma from patients with cirrhosis compared to healthy individuals • The hemostatic changes in patients with cirrhosis of different etiologies are similar but not identical • In comparing the anticoagulant potency of LMWH, apixaban, and dabigatran between patients with cirrhosis due to fatty liver disease or alcohol we found no differences between these distinct etiologies.
ISSN:0049-3848
1879-2472
DOI:10.1016/j.thromres.2016.12.008