Potent Cytotoxic Lignans from Justicia procumbens and Their Effects on Nitric Oxide and Tumor Necrosis Factor-α Production in Mouse Macrophages

A new lignan glycoside, 4-O-alpha-L-arabinopyranosyl-(1' "-->2' ')-beta-D-apiofuranosyldiphyllin (2), named procumbenoside A, and 11 known compounds were isolated from the whole plant of Justicia procumbens. The structure of 2 was established by spectral analysis and chemical...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2002-03, Vol.65 (3), p.379-381
Main Authors: DAY, Shiow-Hwa, LIN, Yi-Chen, TSAI, Mei-Lin, TSAO, Lo-Ti, KO, Horng-Huey, CHUNG, Mei-Ing, LEE, Jeng-Chang, WANG, Jih-Pyang, WON, Shen-Jeu, LIN, Chun-Nan
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
Benzodioxoles
Biological and medical sciences
Cell Line, Transformed - drug effects
Dioxolanes - pharmacology
Drug Screening Assays, Antitumor
General pharmacology
Glycosides - chemistry
Glycosides - isolation & purification
Glycosides - pharmacology
Inhibitory Concentration 50
Lignans - chemistry
Lignans - isolation & purification
Lignans - pharmacology
Lipopolysaccharides - administration & dosage
Macrophage Activation
Macrophages - drug effects
Medical sciences
Mice
Mice, Inbred Strains
Nitric Oxide - analysis
Nuclear Magnetic Resonance, Biomolecular
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plants, Medicinal - chemistry
Spectrophotometry, Ultraviolet
Taiwan
Tumor Necrosis Factor-alpha - analysis
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Summary:A new lignan glycoside, 4-O-alpha-L-arabinopyranosyl-(1' "-->2' ')-beta-D-apiofuranosyldiphyllin (2), named procumbenoside A, and 11 known compounds were isolated from the whole plant of Justicia procumbens. The structure of 2 was established by spectral analysis and chemical methods. The known compounds justicidin A (1), diphyllin (3), and tuberculatin (4) showed potent cytotoxic effects against a number of cancer cells in vitro. Compounds 1 and 4 also strongly enhanced tumor-necrosis factor-alpha (TNF-alpha) generation from mouse macrophage-like RAW 264.7 cells stimulated with lipopolysaccharide (LPS).
ISSN:0163-3864
1520-6025
DOI:10.1021/np0101651