New Diterpene Glycosides of the Fungus Acremonium striatisporum Isolated from a Sea Cucumber

Three new diterpene glycosides, virescenosides O (1), P (2), and Q (3), have been isolated from a marine strain of Acremonium striatisporum KMM 4401 associated with the holothurian Eupentacta fraudatrix. Their structures were determined on the basis of HRMALDIMS and NMR data as beta-D-altropyranosid...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2002-05, Vol.65 (5), p.641-644
Main Authors: AFIYATULLOV, Shamil Sh, KALINOVSKY, Anatoly I., KUZNETSOVA, Tatyana A., ISAKOV, Vladimir V., PIVKIN, Mikhail V., DMITRENOK, Pavel S., ELYAKOV, George B.
Format: Article
Language:English
Subjects:
Acremonium - chemistry
Acremonium striatisporum
Animals
Antineoplastic Agents - chemistry
Antineoplastic Agents - isolation & purification
Antineoplastic Agents - pharmacology
Carcinoma, Ehrlich Tumor
Circular Dichroism
diterpene glycosides
Diterpenes - chemistry
Diterpenes - isolation & purification
Diterpenes - pharmacology
Eupentacta fraudatrix
Glycosides - chemistry
Glycosides - isolation & purification
Glycosides - pharmacology
Hydrolysis
Inhibitory Concentration 50
Molecular Structure
natural products
Nuclear Magnetic Resonance, Biomolecular
Sea Cucumbers
Stereoisomerism
virescenosides
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Summary:Three new diterpene glycosides, virescenosides O (1), P (2), and Q (3), have been isolated from a marine strain of Acremonium striatisporum KMM 4401 associated with the holothurian Eupentacta fraudatrix. Their structures were determined on the basis of HRMALDIMS and NMR data as beta-D-altropyranosido-19-isopimara-8(14),15-diene-7alpha,3beta-diol (1), beta-D-altropyranosido-19-7-oxoisopimara-8(9),15-diene-3beta-ol (2), and beta-D-mannopyranosido-19-isopimara-7,15-diene-3beta-ol (3). The cytotoxic activity of the virescenosides was examined.
ISSN:0163-3864
1520-6025
DOI:10.1021/np010503y