Association between herpes simplex virus Types 1 and 2 with cardiac myxoma

Most cases of atrial myxoma are sporadic, and the exact etiology is unknown. We examined if herpes simplex virus (HSV)-1 and HSV-2 antigens and/or DNA could be detected in a cohort of Iranian patients with cardiac myxomas. From July 2004 to June 2014, among a total of 36,703 patients undergoing open...

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Bibliographic Details
Published in:Cardiovascular pathology 2017-03, Vol.27, p.31-34
Main Authors: Anvari, Maryam Sotoudeh, Sabagh, Moud, Goodarzynejad, Hamidreza, Ziaei, Shayan, Boroumand, Mohammad Ali, Pourgholi, Leyla, Jenab, Yaser, Abbasi, Kyomars
Format: Article
Language:English
Subjects:
Adult
Aged
Cardiac myxoma
Female
Heart Neoplasms - virology
Herpes simplex virus
Herpesviridae Infections - epidemiology
Herpesvirus 1, Human
Herpesvirus 2, Human
Humans
Immunohistochemistry
Iran
Male
Middle Aged
Myxoma - virology
Real-Time Polymerase Chain Reaction
Young Adult
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Summary:Most cases of atrial myxoma are sporadic, and the exact etiology is unknown. We examined if herpes simplex virus (HSV)-1 and HSV-2 antigens and/or DNA could be detected in a cohort of Iranian patients with cardiac myxomas. From July 2004 to June 2014, among a total of 36,703 patients undergoing open heart surgeries, consecutive patients with cardiac myxoma who were treated by surgical excision at our center included in this study. Of 73 patients studied, 56% were female with a mean age of 54 years (ranging from 23 to 77 years). Seventy-four myxomas were surgically removed from 73 patients, since one patient had two myxomas which were located on both the right atrium and right ventricle. The materials for this analysis were retrospectively gathered from extracted tumors that stored in a pathology bank of tissue paraffin blocks. The formalin fixed paraffin embedded tissue samples were investigated for HSV genomic DNA by both immunohistochemistry (IHC) and polymerase chain reaction (PCR) analysis. In all 74 cases there was no presence of HSV 1 and HSV 2 infection. This suggests that HSV may not play a role in sporadic cardiac myxomas; however, evidence for such association is currently lacking, and further studies are required to determine such a role. •Most cases of atrial myxoma are sporadic, and the exact etiology is unknown.•It has been hypothesized that HSV may play a role in the pathogenesis of cardiac myxoma.•HSV-1 or HSV-2 antigens and/or DNA was not detected in any of our patient samples with sporadic cardiac myxomas.
ISSN:1054-8807
1879-1336
DOI:10.1016/j.carpath.2016.12.004