Peripheral blood CD4+/CD25+ regulatory T cells in alcoholic patients with Strongyloides stercoralis infection

An increased number of regulatory T (Treg) cells has been reported in patients with HTLV-1 and Strongyloides stercoralis co-infection, suggesting the contribution of these cells to worm survival. As Strongyloides infections have been found to be highly prevalent in chronic alcoholics, we investigate...

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Bibliographic Details
Published in:Parasitology research (1987) 2017-03, Vol.116 (3), p.1071-1074
Main Authors: Ribeiro, Steveen Rios, Covre, Luciana Polaco, Stringari, Lorenzzo Lyrio, da Penha Zago-Gomes, Maria, Gomes, Daniel Cláudio Oliveira, Pereira, Fausto Edmundo Lima
Format: Article
Language:English
Subjects:
Adult
Alcoholism - blood
Alcoholism - immunology
Alcoholism - parasitology
Animals
Biomedical and Life Sciences
Biomedicine
CD4 antigen
Female
Flow Cytometry
Humans
Immunology
Infections
Lymphocyte Count
Lymphocytes T
Male
Medical Microbiology
Microbiology
Middle Aged
Short Communication
Strongyloides stercoralis - physiology
Strongyloidiasis - blood
Strongyloidiasis - immunology
Strongyloidiasis - parasitology
T-Lymphocytes, Regulatory - cytology
T-Lymphocytes, Regulatory - immunology
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Summary:An increased number of regulatory T (Treg) cells has been reported in patients with HTLV-1 and Strongyloides stercoralis co-infection, suggesting the contribution of these cells to worm survival. As Strongyloides infections have been found to be highly prevalent in chronic alcoholics, we investigated the effect of abusive ethanol ingestion on the induction of Treg cells in alcoholic patients with Strongyloides infection. Treg cells were assessed by flow cytometry in the peripheral blood of 12 healthy non-alcoholic (control) and 14 alcoholic patients (alcoholic) without Strongyloides infection and five non-alcoholics (controlSs) and five chronic alcoholics (alcoholSs) with Strongyloides infection. The results showed significantly higher frequencies of Treg cells in the alcoholic, controlSs and alcoholSs group patients than in the control group patients. However, the frequencies of Treg cells did not differ between the alcoholSs and controlSs groups. In conclusion, our results demonstrate that ethanol consumption induced an increase in the number of circulating Treg cells in chronic alcoholics in this study but was unable to potentiate the induction of these cells in alcoholics with Strongyloides infection.
ISSN:0932-0113
1432-1955
DOI:10.1007/s00436-016-5355-0