Mannose Receptor as a Potential Biomarker for Gastric Cancer: A Pilot Study

Background The mannose receptor is an immune adhesion molecule mainly expressed on the surface of antigen-presenting cells such as nonmature dendritic cells and macrophages. This study aimed to investigate mannose receptor expression and its predictive role in papillary gastric cancer patients. Meth...

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Bibliographic Details
Published in:The International journal of biological markers 2017-07, Vol.32 (3), p.278-283
Main Authors: Liu, Deng-Rui, Guan, Quan-Lin, Gao, Ming-Tai, Jiang, Lei, Kang, Hong-Xia
Format: Article
Language:English
Subjects:
Antigen-presenting cells
Biomarkers
Dendritic cells
Gastric cancer
Macrophages
Mannose
Medical prognosis
Prognosis
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Summary:Background The mannose receptor is an immune adhesion molecule mainly expressed on the surface of antigen-presenting cells such as nonmature dendritic cells and macrophages. This study aimed to investigate mannose receptor expression and its predictive role in papillary gastric cancer patients. Methods The expression of the mannose receptor was measured in 120 samples of gastric cancer tissues and corresponding paracarcinoma tissues, by immunohistochemical and quantitative real-time PCR analysis. The relationships between mannose receptor expression and clinicopathological features of gastric cancer patients were analyzed. Results The expression rate of the mannose receptor in gastric cancer cells was 45.8% (54/120), significantly higher than that in the paracarcinoma tissue (20.0%, 36/120) (χ2 = 6.286, p = 0.012). High expression of the mannose receptor was closely related to tumor size, T stage, N stage and Union for International Cancer Control (UICC) stage of gastric cancer (p
ISSN:1724-6008
0393-6155
1724-6008
DOI:10.5301/jbm.5000244