The route from problem to solution in multistep continuous flow synthesis of pharmaceutical compounds

• Published in: Bioorganic & medicinal chemistry 2017-12, Vol.25 (23), p.6180-6189
• Main Authors: Bana, Péter, Örkényi, Róbert, Lövei, Klára, Lakó, Ágnes, Túrós, György István, Éles, János, Faigl, Ferenc, Greiner, István
• Format: Article
• Language: English
• Subjects: Active pharmaceutical ingredient; Continuous flow processing; Continuous purification; Gases - chemistry; Hazardous Substances - chemistry; In-line analytics; Multistep flow synthesis; Pharmaceutical Preparations - analysis; Pharmaceutical Preparations - chemical synthesis; Pharmaceutical Preparations - chemistry; Solvents - chemistry; Telescoping
• ISSN: 0968-0896; 1464-3391
• DOI: 10.1016/j.bmc.2016.12.046

[Display omitted] Recent advances in the field of continuous flow chemistry allow the multistep preparation of complex molecules such as APIs (Active Pharmaceutical Ingredients) in a telescoped manner. Numerous examples of laboratory-scale applications are described, which are pointing towards novel manufacturing processes of pharmaceutical compounds, in accordance with recent regulatory, economical and quality guidances. The chemical and technical knowledge gained during these studies is considerable; nevertheless, connecting several individual chemical transformations and the attached analytics and purification holds hidden traps. In this review, we summarize innovative solutions for these challenges, in order to benefit chemists aiming to exploit flow chemistry systems for the synthesis of biologically active molecules.