Engineered gadolinium-doped carbon dots for magnetic resonance imaging-guided radiotherapy of tumors

Abstract The effectiveness of radiotherapy can decrease due to inaccurate positioning of machinery and inherent radioresistance of tumors. To address this issue, we present a novel theranostic nanoplatform based on gadolinium-doped carbon dots (Gd-doped CDs) designed specifically for magnetic resona...

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Bibliographic Details
Published in:Biomaterials 2017-03, Vol.121, p.109-120
Main Authors: Du, Fengyi, Zhang, Li, Zhang, Lirong, Zhang, Miaomiao, Gong, Aihua, Tan, Youwen, Miao, Jiawen, Gong, Yuhua, Sun, Mingzhong, Ju, Huixiang, Wu, Chaoyang, Zou, Shenqiang
Format: Article
Language:English
Subjects:
Advanced Basic Science
Animals
Carbon - chemistry
Carbon dots
Contrast agents
Contrast Media - chemical synthesis
Dentistry
Gadolinium
Gadolinium DTPA - administration & dosage
Gadolinium DTPA - chemistry
Hep G2 Cells
Humans
Magnetic Resonance Imaging - methods
Mice, Inbred BALB C
Mice, Inbred ICR
MRI
Nanoparticles - chemistry
Nanoparticles - ultrastructure
Neoplasms, Experimental - diagnostic imaging
Neoplasms, Experimental - radiotherapy
Radiation-Sensitizing Agents - administration & dosage
Radiotherapy
Radiotherapy, Image-Guided - methods
Theranostic Nanomedicine - methods
Treatment Outcome
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Summary:Abstract The effectiveness of radiotherapy can decrease due to inaccurate positioning of machinery and inherent radioresistance of tumors. To address this issue, we present a novel theranostic nanoplatform based on gadolinium-doped carbon dots (Gd-doped CDs) designed specifically for magnetic resonance imaging (MRI)-guided radiotherapy of tumors. The Gd-doped CDs (∼18nm) with dispersibility in water and stable photoluminescence were synthesized via a one-step hydrothermal approach. After tail vein injection of the Gd-doped CDs, they exhibited a relatively long circulation time (∼6 h), enabled efficient passive tumor targeting. Gd-doped CDs accumulate in the kidney and could be cleared out of the body from bladder. Importantly, they exhibited favorable biocompatibility with excellent performance in longitudinal relaxivity rate ( r 1 ) of 6.45 mM-1 S-1 and radiosensitization enhancements. These results show that Gd-doped CDs are excellent T1 contrast agents and radiosensitizers, possessing great promise for MRI-guided radiotherapy of tumors.
ISSN:0142-9612
1878-5905
DOI:10.1016/j.biomaterials.2016.07.008