Effects of Deltorphin II and Its Retroenantio Analog on Cardiac Tolerance to Ischemia and Reperfusion

Selective agonist of δ 2 -opioid receptors deltorphin II and its retroenantio analog (0.12 mg/kg intravenously) were preventively injected to male Wistar rats 15 min prior to 45-min coronary occlusion or 5 min before 120-min reperfusion. Administration of deltorphin II before artery occlusion and be...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2017, Vol.162 (3), p.306-309
Main Authors: Mukhomedzyanov, A. V., Maslov, L. N., Ovchinnikov, M. V., Sidorova, M. V., Pei, J. M., Tsibul’nikov, S. Yu, Tsepokina, A. V., Khutornaya, M. V., Kutikhin, A. G.
Format: Article
Language:English
Subjects:
Amino acids
Analgesics, Opioid - pharmacology
Animals
Arrhythmia
Arrhythmias, Cardiac - drug therapy
Arrhythmias, Cardiac - metabolism
Arrhythmias, Cardiac - physiopathology
Biomedical and Life Sciences
Biomedicine
Blood Pressure - drug effects
Cardiac arrhythmia
Cardiotonic Agents - pharmacology
Cell Biology
Cerebrovascular Disorders
Coronary Vessels - surgery
Deltorphin II
Endogenous opioids
General Pathology and Pathophysiology
Heart
Heart diseases
Heart Rate - drug effects
Injections, Intravenous
Internal Medicine
Ischemia
Laboratory Medicine
Male
Myocardial infarction
Myocardial Reperfusion Injury - drug therapy
Myocardial Reperfusion Injury - metabolism
Myocardial Reperfusion Injury - physiopathology
Occlusion
Oligopeptides - pharmacology
Opioid receptors
Pathology
Rats
Rats, Wistar
Receptors, Opioid, delta - agonists
Receptors, Opioid, delta - metabolism
Reperfusion
Rodents
Stereoisomerism
Ventricle
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Summary:Selective agonist of δ 2 -opioid receptors deltorphin II and its retroenantio analog (0.12 mg/kg intravenously) were preventively injected to male Wistar rats 15 min prior to 45-min coronary occlusion or 5 min before 120-min reperfusion. Administration of deltorphin II before artery occlusion and before reperfusion decreased the infarct size/area at risk ratio. Deltorphin II prevented the appearance of ischemia-provoked ventricular arrhythmias and exerted no effect on HR and BP (systolic and diastolic). The retroenantio analog of deltorphin II produced no antiarrhythmic or infarct - limiting effects, but reduced HR without affecting BP. Deltorphin II can be viewed as a promising prototype for a medicinal remedy to treat acute myocardial infarction.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-017-3601-9