Nitrogen Oxide, Endothelin-1, and Serotonin in the Blood of Immature Spontaneously Hypertensive Rats

• Published in: Bulletin of experimental biology and medicine 2017, Vol.162 (3), p.310-312
• Main Authors: Chibireva, M. D., Aflyatumova, G. N., Matveeva, V. L., Bilalova, D. F., Kuz’mina, O. I., Sadykova, D. I., Nigmatullina, R. R.
• Format: Article
• Language: English
• Subjects: Adolescents; Age Factors; Animals; Biomedical and Life Sciences; Biomedicine; Blood Platelets - metabolism; Blood Platelets - pathology; Blood Pressure; Cell Biology; Children; Endothelin; Endothelin 1; Endothelin-1 - blood; Endothelins; Endothelium; Endothelium, Vascular - metabolism; Endothelium, Vascular - physiopathology; Hypertension; Hypertension - blood; Hypertension - physiopathology; Internal Medicine; Laboratory Medicine; Male; Nitric Oxide - blood; Nitrogen oxides; Pathology; Phenols (Class of compounds); Platelet Count; Platelets; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rodents; Serotonin; Serotonin - blood; Vasoactive agents
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-017-3602-8

Endothelial function is an early and sensitive marker of subclinical increase of BP in children and adolescents. It is associated with an imbalance of the key vasoactive factors (NO, endothelin-1, and serotonin). Immature spontaneously hypertensive rats (SHR line) are characterized by increased plasma concentrations of NO and endothelin-1 (by 14.7% and 2.9 times, respectively) and increased serotonin content in the plasma and platelets (by 2.7 and 2.3 times, respectively) in comparison with Wistar-Kyoto rats. Platelet count in the blood of SHR rats is by 50% higher than in Wistar-Kyoto rats.