Proteomic Study of Blood Serum in Coronary Atherosclerosis

Changes in the blood serum proteins were assessed in men with coronary atherosclerosis and without coronary heart disease. Proteins were separated by 2D-electrophoresis, protein fractions were identified by their peptide fingerprint by MALDI method; fractions with more than twofold increase in prote...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2017, Vol.162 (3), p.343-345
Main Authors: Stakhneva, E. M., Meshcheryakova, I. A., Demidov, E. A., Starostin, K. V., Ragino, Yu. I., Peltek, S. E., Voevoda, M. I.
Format: Article
Language:English
Subjects:
Adult
Arteriosclerosis
Atherosclerosis
Biological products
Biomedical and Life Sciences
Biomedicine
Blood
Blood proteins
Cardiac patients
Cardiovascular disease
Case-Control Studies
Cell Biology
Ceruloplasmin
Ceruloplasmin - metabolism
Commodity futures
Complement C4 - metabolism
Complement component C4
Coronary artery disease
Coronary Artery Disease - blood
Coronary Artery Disease - diagnosis
Coronary Artery Disease - pathology
Coronary heart disease
Electrophoresis, Gel, Two-Dimensional
Health risk assessment
Heart diseases
Heart failure
Humans
Internal Medicine
Laboratory Medicine
Male
Mass spectrometry
Middle Aged
Pathology
Proteins
Proteomics - methods
Serum proteins
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
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Description
Summary:Changes in the blood serum proteins were assessed in men with coronary atherosclerosis and without coronary heart disease. Proteins were separated by 2D-electrophoresis, protein fractions were identified by their peptide fingerprint by MALDI method; fractions with more than twofold increase in protein level were determined. In blood serum of patients with coronary atherosclerosis, the content of C4 complement protein increased and ceruloplasmin level decreased, which is typical of heart failure and coronary heart disease.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-017-3611-7