The DLNO /DLCO ratio: physiological significance and clinical implications

Highlights • DLNO /DLCO is a straightforward measurement of the ratio of the diffusing capacities of the lung for nitric oxide (NO) and carbon monoxide (CO). DLNO mostly reflects the Dm or membrane component and DLCO the θVc or red cell component. • The DLNO /DLCO ratio is positively related to the...

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Bibliographic Details
Published in:Respiratory physiology & neurobiology 2017-07, Vol.241, p.17-22
Main Authors: Hughes, J.M.B, Dinh-Xuan, A.T
Format: Article
Language:English
Subjects:
Carbon monoxide
Diffusing capacity
Gas exchange
Lung function
Medical Education
Nitric oxide
Pulmonary/Respiratory
Transfer factor
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Summary:Highlights • DLNO /DLCO is a straightforward measurement of the ratio of the diffusing capacities of the lung for nitric oxide (NO) and carbon monoxide (CO). DLNO mostly reflects the Dm or membrane component and DLCO the θVc or red cell component. • The DLNO /DLCO ratio is positively related to the DmCO /Vc ratio in a curvilinear function, independent of the absolute values of DLNO or DLCO. • In clinical studies, a raised DLNO /DLCO ratio (≥110% predicted) is associated with pulmonary vascular disease, and a low DLNO /DLCO ratio (≤95%) accompanies interstitial lung disease with fibrosis.
ISSN:1569-9048
1878-1519
DOI:10.1016/j.resp.2017.01.002