Microparticles: Inflammatory and haemostatic biomarkers in Polycystic Ovary Syndrome

Polycystic Ovary Syndrome (PCOS) is associated with a chronic low-grade inflammation and predisposition to hemostatic and atherosclerotic complications. This case-control study evaluated the microparticles (MPs) profile in patients with the PCOS and related these MPs to clinical and biochemical para...

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Bibliographic Details
Published in:Molecular and cellular endocrinology 2017-03, Vol.443, p.155-162
Main Authors: Carvalho, L.M.L., Ferreira, C.N., Sóter, M.O., Sales, M.F., Rodrigues, K.F., Martins, S.R., Candido, A.L., Reis, F.M., Silva, I.F.O., Campos, F.M.F., Gomes, K.B.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biomarkers - metabolism
Case-Control Studies
Cell-Derived Microparticles - metabolism
Endothelial cells
Female
Hemostatics - metabolism
Humans
Inflammation - pathology
Leukocytes
Microparticles
Platelets
Polycystic Ovary Syndrome
Polycystic Ovary Syndrome - metabolism
Polycystic Ovary Syndrome - pathology
Tissue factor
Young Adult
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Summary:Polycystic Ovary Syndrome (PCOS) is associated with a chronic low-grade inflammation and predisposition to hemostatic and atherosclerotic complications. This case-control study evaluated the microparticles (MPs) profile in patients with the PCOS and related these MPs to clinical and biochemical parameters. MPs derived from platelets (PMPs), leuckocytes (LMPs) and endothelial cells (EMPs) were evaluated, as well as MPs expressing tissue factor (TFMPs), by flow cytometry, comparing women with PCOS (n = 50) and a healthy control group (n = 50). PCOS women presented increased total MPs, PMPs, LMPs and EMPs levels when compared to control group (all p 
ISSN:0303-7207
1872-8057
DOI:10.1016/j.mce.2017.01.017