Body regions have an impact on the collagen/elastin index of the skin measured by non‐invasive in vivo vertical two‐photon microscopy

It is known that the collagen and elastin fibre structures are changing with age. There is little knowledge about the influence of body area as these investigations have been limited for ethical reasons, so far. Thus, modified non‐invasive two‐photon microscopy was used providing vertical optical se...

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Bibliographic Details
Published in:Experimental dermatology 2017-09, Vol.26 (9), p.822-824
Main Authors: Czekalla, Carolin, Schönborn, Karl Heinz, Döge, Nadine, Jung, Sora, Darvin, Maxim E., Lademann, Jürgen, Meinke, Martina C.
Format: Article
Language:English
Subjects:
Adult
Aged
autofluorescence
Collagen
Collagen - analysis
Elastin
Elastin - analysis
Ethics
Female
Healthy Volunteers
Humans
Male
Microscopy
Middle Aged
Pilot Projects
SAAID
second harmonic generation
Skin
Skin Aging
T cell receptors
wide‐field 2PM
Young Adult
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Summary:It is known that the collagen and elastin fibre structures are changing with age. There is little knowledge about the influence of body area as these investigations have been limited for ethical reasons, so far. Thus, modified non‐invasive two‐photon microscopy was used providing vertical optical sections of second harmonic generation and autofluorescence to calculate the collagen‐to‐elastin ratio and its alterations depending on the investigated body site in vivo. The results of this study indicate that the impact of different body areas could be higher than the influence of age and should be considered in future studies.
ISSN:0906-6705
1600-0625
DOI:10.1111/exd.13283