Type I Interferon in Malaria: A Balancing Act

Type I interferons (IFN-Is) can now be considered as the wedge that balances clinical protection to malaria. New studies recently highlighted a central role for IFN-Is in orchestrating an immunoregulatory network leading to the dampening of proinflammatory responses, expansion of type 1 regulatory (...

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Bibliographic Details
Published in:Trends in parasitology 2017-04, Vol.33 (4), p.257-260
Main Authors: Mooney, Jason Paul, Wassmer, Samuel Crocodile, Hafalla, Julius Clemence
Format: Article
Language:English
Subjects:
Animals
Cell Proliferation
Dendritic Cells - immunology
Gastroenterology and Hepatology
Humans
IL-10
Immunity, Humoral - immunology
immunoregulation
Infectious Disease
Interferon
Interferon Type I - metabolism
Malaria - immunology
Models, Biological
Plasmodium
T-Lymphocytes, Regulatory - cytology
T-Lymphocytes, Regulatory - immunology
Tr1
Type I interferon
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Summary:Type I interferons (IFN-Is) can now be considered as the wedge that balances clinical protection to malaria. New studies recently highlighted a central role for IFN-Is in orchestrating an immunoregulatory network leading to the dampening of proinflammatory responses, expansion of type 1 regulatory (Tr1) cells, and restriction of humoral immunity during malaria blood stage infection. Plasmacytoid dendritic cells (pDCs) were identified as the major source of IFN-Is. Here, we integrate the findings and provide a model for the mechanisms involved.
ISSN:1471-4922
1471-5007
DOI:10.1016/j.pt.2016.12.010