Decatamariic acid, a new mitochondrial respiration inhibitor discovered by pesticidal screening using drug-sensitive Saccharomyces cerevisiae

A new decalin, decatamariic acid, was isolated from a cultured broth of the fungus Aspergillus tamarii FKI-6817. Its absolute configuration was elucidated by NMR and electronic circular dichroism. Decatamariic acid (10 μ M ) elicited ~50% inhibition of the ATP production in mitochondria isolated fro...

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Bibliographic Details
Published in:Journal of antibiotics 2017-04, Vol.70 (4), p.395-399
Main Authors: Watanabe, Yoshihiro, Suga, Takuya, Narusawa, Satomi, Iwatsuki, Masato, Nonaka, Kenichi, Nakashima, Takuji, Shinohara, Yasuo, Shiotsuki, Takahiro, Ichimaru, Naoya, Miyoshi, Hideto, Asami, Yukihiro, Ōmura, Satoshi, Shiomi, Kazuro
Format: Article
Language:English
Subjects:
631/154/309/2144
639/638/403/936
Absolute configuration
Adenosine Triphosphate - antagonists & inhibitors
Adenosine Triphosphate - biosynthesis
Aspergillus - chemistry
Aspergillus - classification
Bacteriology
Biomedical and Life Sciences
Bioorganic Chemistry
Circular dichroism
Decalin
Dichroism
Drug Evaluation, Preclinical
Electron transport
Fermentation
Fungi
Life Sciences
Magnetic Resonance Spectroscopy
Medicinal Chemistry
Microbiology
Mitochondria
Mitochondria - drug effects
Mitochondria - metabolism
Molecular Conformation
Naphthalenes - chemistry
Naphthalenes - pharmacology
NMR
Nuclear magnetic resonance
Organic Chemistry
original-article
Oxygen Consumption - drug effects
Pesticides
Pesticides - chemistry
Pesticides - pharmacology
Respiratory enzymes
Saccharomyces cerevisiae
Saccharomyces cerevisiae - drug effects
Yeast
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Summary:A new decalin, decatamariic acid, was isolated from a cultured broth of the fungus Aspergillus tamarii FKI-6817. Its absolute configuration was elucidated by NMR and electronic circular dichroism. Decatamariic acid (10 μ M ) elicited ~50% inhibition of the ATP production in mitochondria isolated from wild-type Saccharomyces cerevisiae without affecting the activities of respiratory enzymes. The action manner of this compound may be interesting as a possible seed for new pesticides.
ISSN:0021-8820
1881-1469
DOI:10.1038/ja.2016.164