Trachyspic acid 19-butyl ester, a new inhibitor of Plk1 polo box domain-dependent recognition from uncharacterized fungus RKGS-F2684

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Bibliographic Details
Published in:Journal of antibiotics 2017-05, Vol.70 (5), p.705-707
Main Authors: Nogawa, Toshihiko, Ogita, Noriko, Futamura, Yushi, Negishi, Shigenori, Watanabe, Nobumoto, Osada, Hiroyuki
Format: Article
Language:English
Subjects:
101/47
101/58
631/154/309/507
631/92/349
82/6
Acids
Antibiotics
Bacteriology
Biomedical and Life Sciences
Bioorganic Chemistry
Cell Cycle Proteins - antagonists & inhibitors
Cell division
Clinical trials
Enzyme Inhibitors - chemistry
Enzyme Inhibitors - isolation & purification
Enzyme Inhibitors - pharmacology
Fungi
Fungi - metabolism
High-Throughput Screening Assays - methods
Kinases
Life Sciences
Medicinal Chemistry
Metabolites
Microbiology
Organic Chemistry
Polo-Like Kinase 1
Protein Serine-Threonine Kinases - antagonists & inhibitors
Proteins
Proto-Oncogene Proteins - antagonists & inhibitors
Spiro Compounds - chemistry
Spiro Compounds - isolation & purification
Spiro Compounds - pharmacology
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Description
Summary:
ISSN:0021-8820
1881-1469
DOI:10.1038/ja.2016.167