Transcriptional dynamics of tail regeneration in Xenopus tropicalis

In contrast to humans, many amphibians are able to rapidly and completely regenerate complex tissues, including entire appendages. Following tail amputation, Xenopus tropicalis tadpoles quickly regenerate muscle, spinal cord, cartilage, vasculature and skin, all properly patterned in three dimension...

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Bibliographic Details
Published in:Genesis (New York, N.Y. : 2000) N.Y. : 2000), 2017-01, Vol.55 (1-2), p.n/a
Main Authors: Chang, Jessica, Baker, Julie, Wills, Andrea
Format: Article
Language:English
Subjects:
Amphibian
Animals
Apoptosis - genetics
Gene Expression Regulation, Developmental
genomics
Larva - genetics
Larva - growth & development
organism
process
Regeneration - genetics
Sequence Analysis, RNA
Signal Transduction - genetics
Tail - growth & development
transcription
Transcription, Genetic
Xenopus - genetics
Xenopus - growth & development
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Summary:In contrast to humans, many amphibians are able to rapidly and completely regenerate complex tissues, including entire appendages. Following tail amputation, Xenopus tropicalis tadpoles quickly regenerate muscle, spinal cord, cartilage, vasculature and skin, all properly patterned in three dimensions. To better understand the molecular basis of this regenerative competence, we performed a transcriptional analysis of the first 72 h of tail regeneration using RNA‐Seq. Our analysis refines the windows during which many key biological signaling processes act in regeneration, including embryonic patterning signals, immune responses, bioelectrical signaling and apoptosis. Our work provides a deep database for researchers interested in appendage regeneration, and points to new avenues for further study.
ISSN:1526-954X
1526-968X
DOI:10.1002/dvg.23015