Impact on Clinical Outcomes of Periodic Leg Movements During Sleep in Hospitalized Patients Following Acute Decompensated Heart Failure

• Published in: Circulation Journal 2017/03/24, Vol.81(4), pp.495-500
• Main Authors: Yatsu, Shoichiro, Kasai, Takatoshi, Suda, Shoko, Matsumoto, Hiroki, Shiroshita, Nanako, Kato, Mitsue, Kawana, Fusae, Murata, Azusa, Kato, Takao, Hiki, Masaru, Daida, Hiroyuki
• Format: Article
• Language: English
• Subjects: Acute Disease; Aged; Cause of Death; Female; Heart Failure - complications; Heart Failure - mortality; Heart Failure, Systolic - complications; Heart Failure, Systolic - mortality; Hospitalization; Humans; Leg - physiopathology; Male; Middle Aged; Polysomnography; Restless Legs Syndrome - mortality; Restless Legs Syndrome - physiopathology; Sleep; Sleep Wake Disorders - etiology; Sleep Wake Disorders - mortality; Stroke Volume; Systolic heart failure
• ISSN: 1346-9843; 1347-4820
• DOI: 10.1253/circj.CJ-16-0934

Background:Periodic leg movements during sleep (PLM) are characterized by regularly recurring movement of the legs during sleep. Although PLM is common and a predictor of death in patients with chronic heart failure, the clinical significance of PLM in hospitalized patients with a reduced left ventricular ejection fraction (LVEF) following acute decompensated heart failure (ADHF) remains unknown.Methods and Results:After initial improvement of acute signs and symptoms of ADHF, 94 consecutive patients with reduced LVEF who underwent polysomnography were enrolled. They were divided into 2 groups based on the presence or absence of severe PLM defined as PLM index ≥30. The risks for clinical events, composite of all-cause death and rehospitalization, were assessed using a stepwise multivariable Cox proportional model including variables showing P