The sphingosine-1-phosphate receptor 1 agonist SEW2871 reduces Tau-Ser262 phosphorylation in rat hippocampal slices

Highlights • Tau-Ser262 phosphorylation is selectively reduced following S1PR1 activation in rat hippocampus. • The effect is requiring AMPKα inactivation by the protein phosphatase 2A (PP2A). • Experiments to test the pharmacological relevance of these observations in Tau-related pathologies are su...

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Bibliographic Details
Published in:Brain research 2017-03, Vol.1658, p.51-59
Main Authors: St-Cyr Giguère, Frédéric, Attiori Essis, Suzanne, Chagniel, Laure, Germain, Marc, Cyr, Michel, Massicotte, Guy
Format: Article
Language:English
Subjects:
Amino Acid Sequence
AMP-Activated Protein Kinases - metabolism
AMPK
Animals
Blotting, Western
Central Nervous System Agents - pharmacology
Drug Evaluation, Preclinical
Hippocampus
Hippocampus - drug effects
Hippocampus - metabolism
Isoxazoles - pharmacology
Male
Molecular Structure
Neurology
Oxadiazoles - chemistry
Oxadiazoles - pharmacology
Phosphorylation - drug effects
Protein Phosphatase 2 - metabolism
Rats, Sprague-Dawley
Receptors, Lysosphingolipid - agonists
Receptors, Lysosphingolipid - metabolism
S1P receptors
Tau phosphorylation
tau Proteins - genetics
tau Proteins - metabolism
Thiophenes - chemistry
Thiophenes - pharmacology
Tissue Culture Techniques
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Summary:Highlights • Tau-Ser262 phosphorylation is selectively reduced following S1PR1 activation in rat hippocampus. • The effect is requiring AMPKα inactivation by the protein phosphatase 2A (PP2A). • Experiments to test the pharmacological relevance of these observations in Tau-related pathologies are suggested.
ISSN:0006-8993
1872-6240
DOI:10.1016/j.brainres.2017.01.014