Tumor infiltrating lymphocytes in gastrointestinal tumors: controversies and future clinical implications

Highlights • Different techniques can be used for the assessment of tumor-infiltrating lymphocytes (TILs), providing information about the extent, composition, density and functional profile of the immune infiltrate with prognostic and predictive implications. • High mutational load in microsatellit...

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Bibliographic Details
Published in:Critical reviews in oncology/hematology 2017-02, Vol.110, p.106-116
Main Authors: Solinas, Cinzia, Pusole, Grazia, Demurtas, Laura, Puzzoni, Marco, Mascia, Roberta, Morgan, Gilberto, Giampieri, Riccardo, Scartozzi, Mario
Format: Article
Language:English
Subjects:
Animals
Biomarkers, Tumor - analysis
Gastrointestinal Neoplasms - chemistry
Gastrointestinal Neoplasms - immunology
Gastrointestinal Neoplasms - therapy
Gastrointestinal tumors
Hematology, Oncology and Palliative Medicine
Humans
Immunotherapy
Lymphocytes, Tumor-Infiltrating - immunology
Microsatellite instability
Prognosis
Tumor infiltrating lymphocytes
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Summary:Highlights • Different techniques can be used for the assessment of tumor-infiltrating lymphocytes (TILs), providing information about the extent, composition, density and functional profile of the immune infiltrate with prognostic and predictive implications. • High mutational load in microsatellite instable tumors is correlated with higher immune infiltration and better responses to the immune-checkpoint blockade. • TILs might have future role in the selection of the ideal candidates for immunotherapy.
ISSN:1040-8428
1879-0461
DOI:10.1016/j.critrevonc.2016.11.016