Slow gait speed is an independent predictor of early death in older cancer outpatients: Results from a prospective cohort study

Objective To assess the predictive value of gait speed for early death in older outpatients with cancer. Design Prospective bicentric observational cohort study. Setting The Physical Frailty in Elder Cancer patients (PF-EC) study (France). Participants One hundred and ninety outpatients with cancer...

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Bibliographic Details
Published in:The Journal of nutrition, health & aging health & aging, 2017-02, Vol.21 (2), p.202-206
Main Authors: Pamoukdjian, Frédéric, Lévy, V., Sebbane, G., Boubaya, M., Landre, T., Bloch-Queyrat, C., Paillaud, E., Zelek, L.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Aging
C-Reactive Protein - metabolism
Cancer
Chemotherapy
Cohort analysis
Epidemiology
Female
Follow-Up Studies
Frailty
France
Gait
Geriatric Assessment
Geriatrics
Geriatrics/Gerontology
Hospitals
Humans
Male
Medicine
Medicine & Public Health
Mortality
Multivariate Analysis
Neoplasms - mortality
Neoplasms - physiopathology
Neurosciences
Nutrition
Oncology
Outpatients
Primary Care Medicine
Proportional Hazards Models
Prospective Studies
Quality of Life Research
Walking Speed
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Summary:Objective To assess the predictive value of gait speed for early death in older outpatients with cancer. Design Prospective bicentric observational cohort study. Setting The Physical Frailty in Elder Cancer patients (PF-EC) study (France). Participants One hundred and ninety outpatients with cancer during the first 6 months of follow up in the PF-EC study. Measurements The association between usual gait speed over 4 m alone (GS) or included in the short physical performance battery (SPPB) and overall survival within 6 months following a comprehensive geriatric assessment (CGA). A Cox proportional-hazard regression model was performed in non-survivors for clinical factors from the CGA, along with c reactive protein (CRP). Two models were created to assess GS alone and from inclusion in the SPPB. Results The mean age was 80.6 years, and 50.5% of the participants were men. Death occurred in 11% (n=22) of the participants within the 6 month follow up period. Of these participants, 98% had solid cancers, and 33% had a metastatic disease. A GS < 0.8 m/s (HR=5.6, 95%CI=1.6-19.7, p=0.007), a SPPB < 9 (HR=5.8, 95%CI=1.6-20.9, p=0.007) and a CRP of 50 mg/l or greater (p
ISSN:1279-7707
1760-4788
DOI:10.1007/s12603-016-0734-x