Saccharomyces boulardii administration can inhibit the formation of gastric lymphoid follicles induced by Helicobacter suis infection

• Published in: Pathogens and disease 2017-01, Vol.75 (1), p.ftx006
• Main Authors: Yang, Lin, Tian, Zi-bin, Yu, Ya-nan, Zhang, Cui-ping, Li, Xiao-yu, Mao, Tao, Jing, Xue, Zhao, Wen-jun, Ding, Xue-li, Yang, Ruo-ming, Zhang, Shuai-qing
• Format: Article
• Language: English
• Subjects: Animals; Bacterial infections; beta-Defensins - biosynthesis; Cytokines; Cytokines - genetics; Cytokines - metabolism; Female; Follicles; Fungi; Gastric juice; Gastric Juice - immunology; Gastric mucosa; Helicobacter heilmannii - physiology; Helicobacter Infections - microbiology; Helicobacter suis; Immunoglobulin A; Immunoglobulin A - immunology; Immunoglobulin A, Secretory - immunology; Infections; Inflammation; Inflammation Mediators - metabolism; Intestine; Intestines - immunology; Intestines - metabolism; Intestines - microbiology; Lymphoma; Mice; Microbial Interactions - immunology; Mucosal-associated lymphoid tissue; Probiotics - administration & dosage; Saccharomyces boulardii; Saccharomyces boulardii - physiology; Secretions; Stomach; Stomach - immunology; Stomach - microbiology; Stomach - pathology; Time Factors
• ISSN: 2049-632X; 2049-632X
• DOI: 10.1093/femspd/ftx006

Abstract Helicobacter suis has a greater tendency to induce gastric mucosa-associated lymphoid tissue lymphoma compared with other Helicobacter species in humans and animals. Saccharomyces boulardii has been established as an adjunct to H. pylori eradication treatment, but the effect of S. boulardii administration alone on Helicobacter infection remains unclear. Here, we found that S. boulardii administration effectively decreased the bacterial load of H. suis and inhibited the formation of lymphoid follicles in the stomach post-infection. The levels of H. suis-specific immunoglobulin A (IgA) and secretory IgA in the gastric juice and small intestinal secretions and the production of mouse β-defensin-3 in the small intestinal secretions were significantly increased by S. boulardii administration at 12 weeks after H. suis infection. In addition, feeding with S. boulardii inhibited the expression of inflammatory cytokines and lymphoid follicle formation-related factors after H. suis infection. These results suggested that S. boulardii may be useful for the prevention and treatment of Helicobacter infection-related diseases in humans. Saccharomyces boulardii can protect against Helicobacter suis infection.