Blood markers of inflammation and endothelial dysfunction in cardioembolic stroke: systematic review and meta-analysis

Context: Various processes including inflammation and endothelial dysfunction have been implicated in the pathogenesis of cardioembolic (CE) strokes. Objective: To review the evidence and investigate the association between immune-inflammatory biomarkers and CE strokes versus other stroke subtypes....

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Bibliographic Details
Published in:Biomarkers 2017-05, Vol.22 (3-4), p.200-209
Main Authors: Piccardi, Benedetta, Giralt, Dolors, Bustamante, Alejandro, Llombart, Victor, García-Berrocoso, Teresa, Inzitari, Domenico, Montaner, Joan
Format: Article
Language:English
Subjects:
biological markers
Biomarkers - blood
C-Reactive Protein - analysis
Cardiovascular disease
Cardiovascular Diseases - complications
Embolism - complications
Endothelium, Vascular - physiopathology
Humans
Inflammation - blood
stroke
Stroke - blood
Stroke - etiology
Stroke - pathology
Stroke - physiopathology
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Summary:Context: Various processes including inflammation and endothelial dysfunction have been implicated in the pathogenesis of cardioembolic (CE) strokes. Objective: To review the evidence and investigate the association between immune-inflammatory biomarkers and CE strokes versus other stroke subtypes. Methods: We systematically reviewed the literature (sources: MEDLINE, web-based register http://stroke-biomarkers.com , reference lists) with quality assessment and meta-analysis of selected articles. Results: The most consistent association was found between C-reactive protein (CRP) and CE strokes when compared to other stroke subtypes (standardized mean difference 0.223 (0.116, 0.343); p 
ISSN:1354-750X
1366-5804
DOI:10.1080/1354750X.2017.1286689