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Blood markers of inflammation and endothelial dysfunction in cardioembolic stroke: systematic review and meta-analysis
Context: Various processes including inflammation and endothelial dysfunction have been implicated in the pathogenesis of cardioembolic (CE) strokes. Objective: To review the evidence and investigate the association between immune-inflammatory biomarkers and CE strokes versus other stroke subtypes....
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| Published in: | Biomarkers 2017-05, Vol.22 (3-4), p.200-209 |
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| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c418t-85298aa76e0e9ebd527528aa0e068a0238d02a863aa8ad4e739ddedf54ff39273 |
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| cites | cdi_FETCH-LOGICAL-c418t-85298aa76e0e9ebd527528aa0e068a0238d02a863aa8ad4e739ddedf54ff39273 |
| container_end_page | 209 |
| container_issue | 3-4 |
| container_start_page | 200 |
| container_title | Biomarkers |
| container_volume | 22 |
| creator | Piccardi, Benedetta Giralt, Dolors Bustamante, Alejandro Llombart, Victor García-Berrocoso, Teresa Inzitari, Domenico Montaner, Joan |
| description | Context: Various processes including inflammation and endothelial dysfunction have been implicated in the pathogenesis of cardioembolic (CE) strokes.
Objective: To review the evidence and investigate the association between immune-inflammatory biomarkers and CE strokes versus other stroke subtypes.
Methods: We systematically reviewed the literature (sources: MEDLINE, web-based register
http://stroke-biomarkers.com
, reference lists) with quality assessment and meta-analysis of selected articles.
Results: The most consistent association was found between C-reactive protein (CRP) and CE strokes when compared to other stroke subtypes (standardized mean difference 0.223 (0.116, 0.343); p |
| doi_str_mv | 10.1080/1354750X.2017.1286689 |
| format | article |
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Objective: To review the evidence and investigate the association between immune-inflammatory biomarkers and CE strokes versus other stroke subtypes.
Methods: We systematically reviewed the literature (sources: MEDLINE, web-based register
http://stroke-biomarkers.com
, reference lists) with quality assessment and meta-analysis of selected articles.
Results: The most consistent association was found between C-reactive protein (CRP) and CE strokes when compared to other stroke subtypes (standardized mean difference 0.223 (0.116, 0.343); p < 0.001)
Conclusions: Our findings confirm a possible association between selected inflammatory biomarkers and CE stroke.</description><identifier>ISSN: 1354-750X</identifier><identifier>EISSN: 1366-5804</identifier><identifier>DOI: 10.1080/1354750X.2017.1286689</identifier><identifier>PMID: 28117601</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>biological markers ; Biomarkers - blood ; C-Reactive Protein - analysis ; Cardiovascular disease ; Cardiovascular Diseases - complications ; Embolism - complications ; Endothelium, Vascular - physiopathology ; Humans ; Inflammation - blood ; stroke ; Stroke - blood ; Stroke - etiology ; Stroke - pathology ; Stroke - physiopathology</subject><ispartof>Biomarkers, 2017-05, Vol.22 (3-4), p.200-209</ispartof><rights>2017 Informa UK Limited, trading as Taylor & Francis Group 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-85298aa76e0e9ebd527528aa0e068a0238d02a863aa8ad4e739ddedf54ff39273</citedby><cites>FETCH-LOGICAL-c418t-85298aa76e0e9ebd527528aa0e068a0238d02a863aa8ad4e739ddedf54ff39273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28117601$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Piccardi, Benedetta</creatorcontrib><creatorcontrib>Giralt, Dolors</creatorcontrib><creatorcontrib>Bustamante, Alejandro</creatorcontrib><creatorcontrib>Llombart, Victor</creatorcontrib><creatorcontrib>García-Berrocoso, Teresa</creatorcontrib><creatorcontrib>Inzitari, Domenico</creatorcontrib><creatorcontrib>Montaner, Joan</creatorcontrib><title>Blood markers of inflammation and endothelial dysfunction in cardioembolic stroke: systematic review and meta-analysis</title><title>Biomarkers</title><addtitle>Biomarkers</addtitle><description>Context: Various processes including inflammation and endothelial dysfunction have been implicated in the pathogenesis of cardioembolic (CE) strokes.
Objective: To review the evidence and investigate the association between immune-inflammatory biomarkers and CE strokes versus other stroke subtypes.
Methods: We systematically reviewed the literature (sources: MEDLINE, web-based register
http://stroke-biomarkers.com
, reference lists) with quality assessment and meta-analysis of selected articles.
Results: The most consistent association was found between C-reactive protein (CRP) and CE strokes when compared to other stroke subtypes (standardized mean difference 0.223 (0.116, 0.343); p < 0.001)
Conclusions: Our findings confirm a possible association between selected inflammatory biomarkers and CE stroke.</description><subject>biological markers</subject><subject>Biomarkers - blood</subject><subject>C-Reactive Protein - analysis</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular Diseases - complications</subject><subject>Embolism - complications</subject><subject>Endothelium, Vascular - physiopathology</subject><subject>Humans</subject><subject>Inflammation - blood</subject><subject>stroke</subject><subject>Stroke - blood</subject><subject>Stroke - etiology</subject><subject>Stroke - pathology</subject><subject>Stroke - physiopathology</subject><issn>1354-750X</issn><issn>1366-5804</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp9kEtv1TAQRi1UREvhJ4C87CYXP2LHYdWHykOqxAYkdtbceCxMHbu1c1vl35P03nbJyiPPmW9Gh5APnG04M-wTl6rtFPu9EYx3Gy6M1qZ_RU641LpRhrVHa63aZoWOydta_zLGpejNG3IsDOedZvyEPFzGnB0dodxiqTR7GpKPMI4whZwoJEcxuTz9wRggUjdXv0vDUy8kOkBxIeO4zTEMtE4l3-JnWuc64Row0IIPAR-fYkacoIEEca6hviOvPcSK7w_vKfn15frn1bfm5sfX71cXN83QcjM1Ri33AnQaGfa4dUp0SiwfDJk2wIQ0jgkwWgIYcC12sncOnVet97IXnTwlZ_vcu5Lvd1gnO4Y6YIyQMO-q5UZzzUXXtguq9uhQcq0Fvb0rYfEyW87sqtw-K7ercntQvsx9PKzYbUd0L1PPjhfgfA8sZnMZ4TGX6OwEc8zFF0hDqFb-f8c_b2qTYA</recordid><startdate>20170519</startdate><enddate>20170519</enddate><creator>Piccardi, Benedetta</creator><creator>Giralt, Dolors</creator><creator>Bustamante, Alejandro</creator><creator>Llombart, Victor</creator><creator>García-Berrocoso, Teresa</creator><creator>Inzitari, Domenico</creator><creator>Montaner, Joan</creator><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170519</creationdate><title>Blood markers of inflammation and endothelial dysfunction in cardioembolic stroke: systematic review and meta-analysis</title><author>Piccardi, Benedetta ; Giralt, Dolors ; Bustamante, Alejandro ; Llombart, Victor ; García-Berrocoso, Teresa ; Inzitari, Domenico ; Montaner, Joan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-85298aa76e0e9ebd527528aa0e068a0238d02a863aa8ad4e739ddedf54ff39273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>biological markers</topic><topic>Biomarkers - blood</topic><topic>C-Reactive Protein - analysis</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular Diseases - complications</topic><topic>Embolism - complications</topic><topic>Endothelium, Vascular - physiopathology</topic><topic>Humans</topic><topic>Inflammation - blood</topic><topic>stroke</topic><topic>Stroke - blood</topic><topic>Stroke - etiology</topic><topic>Stroke - pathology</topic><topic>Stroke - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Piccardi, Benedetta</creatorcontrib><creatorcontrib>Giralt, Dolors</creatorcontrib><creatorcontrib>Bustamante, Alejandro</creatorcontrib><creatorcontrib>Llombart, Victor</creatorcontrib><creatorcontrib>García-Berrocoso, Teresa</creatorcontrib><creatorcontrib>Inzitari, Domenico</creatorcontrib><creatorcontrib>Montaner, Joan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biomarkers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Piccardi, Benedetta</au><au>Giralt, Dolors</au><au>Bustamante, Alejandro</au><au>Llombart, Victor</au><au>García-Berrocoso, Teresa</au><au>Inzitari, Domenico</au><au>Montaner, Joan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Blood markers of inflammation and endothelial dysfunction in cardioembolic stroke: systematic review and meta-analysis</atitle><jtitle>Biomarkers</jtitle><addtitle>Biomarkers</addtitle><date>2017-05-19</date><risdate>2017</risdate><volume>22</volume><issue>3-4</issue><spage>200</spage><epage>209</epage><pages>200-209</pages><issn>1354-750X</issn><eissn>1366-5804</eissn><abstract>Context: Various processes including inflammation and endothelial dysfunction have been implicated in the pathogenesis of cardioembolic (CE) strokes.
Objective: To review the evidence and investigate the association between immune-inflammatory biomarkers and CE strokes versus other stroke subtypes.
Methods: We systematically reviewed the literature (sources: MEDLINE, web-based register
http://stroke-biomarkers.com
, reference lists) with quality assessment and meta-analysis of selected articles.
Results: The most consistent association was found between C-reactive protein (CRP) and CE strokes when compared to other stroke subtypes (standardized mean difference 0.223 (0.116, 0.343); p < 0.001)
Conclusions: Our findings confirm a possible association between selected inflammatory biomarkers and CE stroke.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>28117601</pmid><doi>10.1080/1354750X.2017.1286689</doi><tpages>10</tpages></addata></record> |
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| language | eng |
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| subjects | biological markers Biomarkers - blood C-Reactive Protein - analysis Cardiovascular disease Cardiovascular Diseases - complications Embolism - complications Endothelium, Vascular - physiopathology Humans Inflammation - blood stroke Stroke - blood Stroke - etiology Stroke - pathology Stroke - physiopathology |
| title | Blood markers of inflammation and endothelial dysfunction in cardioembolic stroke: systematic review and meta-analysis |
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