Increase of IRF-1 gene expression and impairment of T regulatory cells suppression activity on patients with myelodysplastic syndrome: a longitudinal one-year study

Highlights • Higher peripheral Treg number in low risk patients with MDS compared to high risk. • Treg suppression activity is impaired in MDS patients. • Increased in vitro cytokine production from MDS patients’ T cells after 12 months. • Negative correlation between IRF-1 and Foxp3 on initial eval...

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Bibliographic Details
Published in:Leukemia research 2017-04, Vol.55, p.6-17
Main Authors: Perazzio, Aline S.B, Oliveira, José Salvador R, Figueiredo, Vera L.P, Ferrari Chauffaille, Maria de Lourdes L
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Cytokines - biosynthesis
Female
Forkhead Transcription Factors - biosynthesis
Foxp3
Gene Expression
Hematology, Oncology and Palliative Medicine
Humans
Immune system
Immune Tolerance
Interferon Regulatory Factor-1 - biosynthesis
Interferon Regulatory Factor-1 - physiology
IRF-1
Longitudinal Studies
Male
Middle Aged
Myelodysplastic syndrome
Myelodysplastic Syndromes - immunology
Myelodysplastic Syndromes - metabolism
T regulatory cells
T-Lymphocytes, Regulatory - immunology
T-Lymphocytes, Regulatory - pathology
T-Lymphocytes, Regulatory - physiology
Time Factors
Treg
Young Adult
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Summary:Highlights • Higher peripheral Treg number in low risk patients with MDS compared to high risk. • Treg suppression activity is impaired in MDS patients. • Increased in vitro cytokine production from MDS patients’ T cells after 12 months. • Negative correlation between IRF-1 and Foxp3 on initial evaluation. • Results suggest a progressive immune hyper activity following MDS evolution.
ISSN:0145-2126
1873-5835
DOI:10.1016/j.leukres.2017.01.008