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Increase of IRF-1 gene expression and impairment of T regulatory cells suppression activity on patients with myelodysplastic syndrome: a longitudinal one-year study

Highlights • Higher peripheral Treg number in low risk patients with MDS compared to high risk. • Treg suppression activity is impaired in MDS patients. • Increased in vitro cytokine production from MDS patients’ T cells after 12 months. • Negative correlation between IRF-1 and Foxp3 on initial eval...

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Published in:	Leukemia research 2017-04, Vol.55, p.6-17
Main Authors:	Perazzio, Aline S.B, Oliveira, José Salvador R, Figueiredo, Vera L.P, Ferrari Chauffaille, Maria de Lourdes L
Format:	Article
Language:	English
Subjects:	Adult Aged Aged, 80 and over Cytokines - biosynthesis Female Forkhead Transcription Factors - biosynthesis Foxp3 Gene Expression Hematology, Oncology and Palliative Medicine Humans Immune system Immune Tolerance Interferon Regulatory Factor-1 - biosynthesis Interferon Regulatory Factor-1 - physiology IRF-1 Longitudinal Studies Male Middle Aged Myelodysplastic syndrome Myelodysplastic Syndromes - immunology Myelodysplastic Syndromes - metabolism T regulatory cells T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - pathology T-Lymphocytes, Regulatory - physiology Time Factors Treg Young Adult
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description	Highlights • Higher peripheral Treg number in low risk patients with MDS compared to high risk. • Treg suppression activity is impaired in MDS patients. • Increased in vitro cytokine production from MDS patients’ T cells after 12 months. • Negative correlation between IRF-1 and Foxp3 on initial evaluation. • Results suggest a progressive immune hyper activity following MDS evolution.
doi_str_mv	10.1016/j.leukres.2017.01.008
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subjects	Adult Aged Aged, 80 and over Cytokines - biosynthesis Female Forkhead Transcription Factors - biosynthesis Foxp3 Gene Expression Hematology, Oncology and Palliative Medicine Humans Immune system Immune Tolerance Interferon Regulatory Factor-1 - biosynthesis Interferon Regulatory Factor-1 - physiology IRF-1 Longitudinal Studies Male Middle Aged Myelodysplastic syndrome Myelodysplastic Syndromes - immunology Myelodysplastic Syndromes - metabolism T regulatory cells T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - pathology T-Lymphocytes, Regulatory - physiology Time Factors Treg Young Adult
title	Increase of IRF-1 gene expression and impairment of T regulatory cells suppression activity on patients with myelodysplastic syndrome: a longitudinal one-year study
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