Automated computer-based CT stratification as a predictor of outcome in hypersensitivity pneumonitis

Background Hypersensitivity pneumonitis (HP) has a variable clinical course. Modelling of quantitative CALIPER-derived CT data can identify distinct disease phenotypes. Mortality prediction using CALIPER analysis was compared to the interstitial lung disease gender, age, physiology (ILD-GAP) outcome...

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Bibliographic Details
Published in:European radiology 2017-09, Vol.27 (9), p.3635-3646
Main Authors: Jacob, Joseph, Bartholmai, B. J., Rajagopalan, S., Karwoski, R., Mak, S. M., Mok, W., Della Casa, G., Sugino, K., Walsh, S. L. F., Wells, A. U., Hansell, D. M.
Format: Article
Language:English
Subjects:
Aged
Alveolitis
Alveolitis, Extrinsic Allergic - diagnostic imaging
Alveolitis, Extrinsic Allergic - mortality
Alveolitis, Extrinsic Allergic - physiopathology
Automation
Carbon monoxide
Computer Applications
Diagnostic Radiology
Equivalence
Female
Fibrosis
Humans
Hypersensitivity
Imaging
Internal Medicine
Interventional Radiology
Kaplan-Meier Estimate
London - epidemiology
Lung diseases
Lung Diseases, Interstitial - diagnostic imaging
Lung Diseases, Interstitial - mortality
Lung Diseases, Interstitial - physiopathology
Male
Mathematical models
Medicine
Medicine & Public Health
Middle Aged
Mortality
Multivariate Analysis
Neuroradiology
Pneumonitis
Predictions
Prognosis
Pulmonary Diffusing Capacity - physiology
Radiology
Respiratory Function Tests
Tomography, X-Ray Computed - methods
Ultrasound
Vital Capacity - physiology
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Summary:Background Hypersensitivity pneumonitis (HP) has a variable clinical course. Modelling of quantitative CALIPER-derived CT data can identify distinct disease phenotypes. Mortality prediction using CALIPER analysis was compared to the interstitial lung disease gender, age, physiology (ILD-GAP) outcome model. Methods CALIPER CT analysis of parenchymal patterns in 98 consecutive HP patients was compared to visual CT scoring by two radiologists. Functional indices including forced vital capacity (FVC) and diffusion capacity for carbon monoxide (DLco) in univariate and multivariate Cox mortality models. Automated stratification of CALIPER scores was evaluated against outcome models. Results Univariate predictors of mortality included visual and CALIPER CT fibrotic patterns, and all functional indices. Multivariate analyses identified only two independent predictors of mortality: CALIPER reticular pattern (p = 0.001) and DLco (p 
ISSN:0938-7994
1432-1084
DOI:10.1007/s00330-016-4697-4