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High-level resistance to meropenem in clinical isolates of Pseudomonas aeruginosa in the absence of carbapenemases: role of active efflux and porin alterations
Highlights • P. aeruginosa from cystic fibrosis patients show high-level carbapenem resistance. • Meropenem was less active than imipenem against these isolates. • No carbapenemases were detected in these isolates. • Resistance mechanisms involved efflux overexpression and absence of OprD porin....
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Published in: | International journal of antimicrobial agents 2016-12, Vol.48 (6), p.740-743 |
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Main Authors: | , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Highlights • P. aeruginosa from cystic fibrosis patients show high-level carbapenem resistance. • Meropenem was less active than imipenem against these isolates. • No carbapenemases were detected in these isolates. • Resistance mechanisms involved efflux overexpression and absence of OprD porin. |
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ISSN: | 0924-8579 1872-7913 |
DOI: | 10.1016/j.ijantimicag.2016.09.012 |