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High-level resistance to meropenem in clinical isolates of Pseudomonas aeruginosa in the absence of carbapenemases: role of active efflux and porin alterations

Highlights • P. aeruginosa from cystic fibrosis patients show high-level carbapenem resistance. • Meropenem was less active than imipenem against these isolates. • No carbapenemases were detected in these isolates. • Resistance mechanisms involved efflux overexpression and absence of OprD porin....

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Published in:International journal of antimicrobial agents 2016-12, Vol.48 (6), p.740-743
Main Authors: Chalhoub, Hussein, Sáenz, Yolanda, Rodriguez-Villalobos, Hector, Denis, Olivier, Kahl, Barbara C, Tulkens, Paul M, Van Bambeke, Françoise
Format: Article
Language:English
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Summary:Highlights • P. aeruginosa from cystic fibrosis patients show high-level carbapenem resistance. • Meropenem was less active than imipenem against these isolates. • No carbapenemases were detected in these isolates. • Resistance mechanisms involved efflux overexpression and absence of OprD porin.
ISSN:0924-8579
1872-7913
DOI:10.1016/j.ijantimicag.2016.09.012