Chest and renal involvements, Birmingham vascular activity score more than 13.5 and five factor score (1996) more than 1 at diagnosis are significant predictors of relapse of microscopic polyangiitis

We investigated whether specified organ involvements, antineutrophil cytoplasmic antibody (ANCA) positivity, Birmingham vasculitis activity score (BVAS) and five factor scores (FFS) at diagnosis could predict relapse of microscopic polyangiitis (MPA). We reviewed the medical records of 90 patients w...

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Bibliographic Details
Published in:Clinical and experimental rheumatology 2017-03, Vol.35 Suppl 103 (1), p.47-54
Main Authors: Oh, Yoon-Jeong, Ahn, Sung Soo, Park, Eun Seong, Jung, Seung Min, Song, Jason Jungsik, Park, Yong-Beom, Lee, Sang-Won
Format: Article
Language:English
Subjects:
Aged
Antibodies, Antineutrophil Cytoplasmic - blood
Biomarkers - blood
Decision Support Techniques
Disease-Free Survival
Female
Humans
Kaplan-Meier Estimate
Kidney Diseases - blood
Kidney Diseases - diagnosis
Kidney Diseases - etiology
Kidney Diseases - therapy
Logistic Models
Lung Diseases - blood
Lung Diseases - diagnosis
Lung Diseases - etiology
Lung Diseases - therapy
Male
Medical Records
Microscopic Polyangiitis - blood
Microscopic Polyangiitis - complications
Microscopic Polyangiitis - diagnosis
Microscopic Polyangiitis - therapy
Middle Aged
Multivariate Analysis
Odds Ratio
Predictive Value of Tests
Recurrence
Remission Induction
Retrospective Studies
Risk Assessment
Risk Factors
Time Factors
Treatment Outcome
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Summary:We investigated whether specified organ involvements, antineutrophil cytoplasmic antibody (ANCA) positivity, Birmingham vasculitis activity score (BVAS) and five factor scores (FFS) at diagnosis could predict relapse of microscopic polyangiitis (MPA). We reviewed the medical records of 90 patients with MPA. We collected clinical and prognostic data, (MPO)-ANCA and proteinase 3 (PR3)-ANCA, BVAS and FFS at diagnosis, and we compared them between the two groups. The optimal cut-off values of BVAS and FFS (1996) for predicting relapse were extrapolated. The mean age of patients (63 women) was 62.3 years and the mean follow-up duration was 41.7 months. At diagnosis, the mean BVAS, FFS (1996) and FFS (2009) of patients in no remission group were higher than those of patients in remission group (p
ISSN:0392-856X