Cross-sectional and longitudinal investigation of human herpesvirus 8 seroprevalence in HIV-1-infected individuals in Osaka, Japan

Abstract Introduction High human herpesvirus 8 (HHV-8) seroprevalence has been reported in men who have sex with men (MSM) and are infected with HIV-1. However, it is unclear when they become infected with HHV-8. Thus, we conducted cross-sectional and longitudinal investigations of HHV-8 seroprevale...

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Published in:Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 2017-04, Vol.23 (4), p.201-205
Main Authors: Watanabe, Dai, Yamamoto, Yudai, Suzuki, Sachiko, Ashida, Misa, Matsumoto, Erina, Yukawa, Satomi, Hirota, Kazuyuki, Ikuma, Motoko, Ueji, Takashi, Kasai, Daisuke, Nishida, Yasuharu, Uehira, Tomoko, Shirasaka, Takuma
Format: Article
Language:English
Subjects:
Antibodies, Viral - blood
Cross-Sectional Studies
Enzyme-Linked Immunosorbent Assay - methods
Hematology, Oncology and Palliative Medicine
Herpesvirus 8, Human - immunology
HHV-8
HIV Infections - blood
HIV Infections - immunology
HIV-1
HIV-1 - immunology
Homosexuality, Male
Humans
Japan
Longitudinal Studies
Male
Seroconversion
Seroepidemiologic Studies
Seroprevalence
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Summary:Abstract Introduction High human herpesvirus 8 (HHV-8) seroprevalence has been reported in men who have sex with men (MSM) and are infected with HIV-1. However, it is unclear when they become infected with HHV-8. Thus, we conducted cross-sectional and longitudinal investigations of HHV-8 seroprevalence in HIV-1-infected individuals in Osaka, Japan. Patients and methods Plasma was collected from 121 individuals infected with HIV-1 and the anti-HHV-8 antibody titer was measured using an enzyme-linked immunosorbent assay with whole virus lysate. Subjects were classified into those with and without a past medical history of HHV-8-associated disease; the latter group was then classified into 3 subgroups based on the assumed route of HIV-1 infection: blood products, homosexual contact, and other routes. HHV-8 seroprevalence was compared among the groups and measured again approximately 3 years after the baseline measurement. The relationship between HHV-8 seropositivity and possible associated factors was also investigated. Results All 15 subjects with HHV-8-associated disease were seropositive, and all 11 subjects in the blood product group were seronegative. In the MSM group, 25 (30%) of 79 subjects were HHV-8 seropositive and, in the non-MSM group, 1 (6%) of 16 subjects was (p 
ISSN:1341-321X
1437-7780
DOI:10.1016/j.jiac.2016.12.007