Effects of acetylcholine and cholinergic antagonists on the activity of nucleus of the solitary tract neurons

Highlights • Acetylcholine depolarizes neurons of both commissural and intermediate NTS. • Nicotinic, but not muscarinic antagonist inhibited ACh effects in the cNTS. • Both nicotinic and muscarinic antagonists reduced ACh-induced responses in iNTS.

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Bibliographic Details
Published in:Brain research 2017-03, Vol.1659, p.136-141
Main Authors: Furuya, Werner I, Colombari, Eduardo, Ferguson, Alastair V, Colombari, Débora S.A
Format: Article
Language:English
Subjects:
Acetylcholine
Acetylcholine - pharmacology
Animals
Atropine - pharmacology
Cholinergic Agonists - pharmacology
Cholinergic Antagonists - pharmacology
Male
Mecamylamine - pharmacology
Membrane Potentials - drug effects
Membrane Potentials - physiology
Muscarinic Antagonists - pharmacology
Muscarinic receptors
Neurology
Neurons - drug effects
Neurons - metabolism
Nicotinic Antagonists - pharmacology
Nicotinic receptors
Patch clamp
Patch-Clamp Techniques
Rats, Sprague-Dawley
Solitary Nucleus - drug effects
Solitary Nucleus - metabolism
Tissue Culture Techniques
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Description
Summary:Highlights • Acetylcholine depolarizes neurons of both commissural and intermediate NTS. • Nicotinic, but not muscarinic antagonist inhibited ACh effects in the cNTS. • Both nicotinic and muscarinic antagonists reduced ACh-induced responses in iNTS.
ISSN:0006-8993
1872-6240
DOI:10.1016/j.brainres.2017.01.027