It is important to measure changes in the bone-conduction threshold when evaluating whether FGF-2 can be used to repair blast-induced total or near-total tympanic membrane perforations

• Published in: American journal of otolaryngology 2017-03, Vol.38 (2), p.267-268
• Main Author: Lou, Xudan
• Format: Article
• Language: English
• Subjects: Acoustic noise; Atelocollagen; Audiometry; Audiometry, Pure-Tone; Biodegradability; Biodegradation; Bone Conduction; Brain; Brain damage; Brain stem; Cell culture; Cochlea; Compression; Deafness; Degeneration; Ear; Eardrum; Embryos; Epidermal growth factor; Epithelium; Explosions; Exposure; Facial nerve; Failure; Fibroblast Growth Factor 2; Fibroblasts; Fractures; Glutamic acid; Growth factors; Hair; Head; Hearing loss; Humans; In vivo methods and tests; Infections; Injuries; Lesions; Military; Military personnel; Nerves; Neural stem cells; Neurodegeneration; Neurons; Neurotoxicity; Noise; Otolaryngology; Overpressure; Personnel; Regression analysis; Risk factors; Statistical analysis; Steroids; Success; Surgery; Surgical implants; Trauma; Tympanic Membrane; Tympanic Membrane Perforation; War
• ISSN: 0196-0709; 1532-818X
• DOI: 10.1016/j.amjoto.2017.01.019

Dear Editor, We would like to comment on the manuscript entitled “Utility of basic fibroblast growth factor in the repair of blast-induced total or near-total tympanic membrane perforations: A pilot study” by Lou et al. The authors simply write (in the Materials and Methods section): “The inclusion criteria were: [1] a traumatic TMP involving >=75% of the entire tympanic membrane (TM) and caused by a blast explosion [2], regular follow-up, and [3] no middle ear infection at the time of the hospital visit.” and “The TM was treated once daily by the direct application of 0.10-0.15mL (2-3 drops) of recombinant bovine bFGF solution (21000IU/5mL). In a study of the use of FGF-2 to repair traumatic TMPs, Lou et al. earlier [7] used multivariate logistic regression analysis to show that histories of chronic otitis media and myringosclerosis were significant risk factors for treatment failure. Blast-induced TMPs usually have inverted edges and fractured eardrum epithelia, both of which may cause middle-ear cholesteatoma [8,9]. [...]processing of inverted edges and the fractured epithelium is vital prior to FGF-2 treatment. References 1 Z. Lou, Z. Lou, Y. Tang, Utility of basic fibroblast growth factor in the repair of blast-induced total or near-total tympanic membrane perforations: a pilot study, Am J Otolaryngol, Vol. 36, Iss. 6, 2015, 794-797 2 N. Sprem, S. Branica, K. Dawidowsky, Tympanoplasty after war blast lesions of the eardrum: retrospective study, Croat Med J, Vol. 42, 2001, 642-645 3 S.K. Sridhara, A. Rivera, P. Littlefield, Tympanoplasty for blast induced perforations: the Walter...