Highly expressed long non-coding RNA FOXD2-AS1 promotes non-small cell lung cancer progression via Wnt/β-catenin signaling

• Published in: Biochemical and biophysical research communications 2017-03, Vol.484 (3), p.586-591
• Main Authors: Rong, Lin, Zhao, Ruixing, Lu, Jinxiu
• Format: Article
• Language: English
• Subjects: Animals; Carcinoma, Non-Small-Cell Lung - metabolism; Carcinoma, Non-Small-Cell Lung - pathology; Cell Proliferation; FOXD2-AS1; Gene Expression Regulation, Neoplastic; Humans; lncRNA; Lung Neoplasms - metabolism; Lung Neoplasms - pathology; Mice, Inbred BALB C; Neoplasm Invasiveness; NSCLC; RNA, Long Noncoding - metabolism; Tumor Cells, Cultured; Up-Regulation; Wnt Signaling Pathway; Wnt/β-catenin signaling
• ISSN: 0006-291X; 1090-2104
• DOI: 10.1016/j.bbrc.2017.01.141

Non-small cell lung cancer (NSCLC) is one of the most common and aggressive tumors around the world. Long-noncoding RNAs (lncRNAs) have been recently shown to play important roles in regulating numerous biological processes including tumor progression. However, the role of lncRNA FOXD2-AS1 in NSCLC remains unclear. In this study, we found that lncRNA FOXD2-AS1 is significantly up-regulated in NSCLC tissues. Loss- and gain-function assays revealed that FOXD2-AS1 promotes NSCLC cell growth and NSCLC tumor progression. Furthermore, we also revealed that FOXD2-AS1 modulates Wnt/β-catenin signaling in NSCLC cells. Taken together, we conclude that lncRNA FOXD2-AS1 promotes NSCLC progression though Wnt/β-catenin signaling. These results suggest that lncRNA FOXD2-AS1 might act as a novel therapeutic target for NSCLC treatment. •FOXD2-AS1 was significantly high in NSCLC tissues.•FOXD2-AS1 promotes NSCLC cell growth and NSCLC tumor progression.•FOXD2-AS1 regulates NSCLC progression via Wnt/β-catenin signaling.