Role of flow cytometry in the diagnostic evaluation of primary immunodeficiency disease

Primary immunodeficiency disease can be broadly categorized into five groups encompassing: (a) combined immunodeficiencies; (b) primarily antibody deficiencies; (c) phagocyte disorders; (d) other well-defined immunodeficiency syndromes; and (e) complement deficiencies. Currently there are greater th...

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Bibliographic Details
Published in:Clinical and Applied Immunology Reviews 2002-10, Vol.2 (6), p.321-335
Main Authors: O'Gorman, Maurice R.G, Scholl, Paul R
Format: Article
Language:English
Subjects:
Flow cytometry
Monoclonal antibody
Primary immunodeficiency disease
Routine immunophenotyping
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Summary:Primary immunodeficiency disease can be broadly categorized into five groups encompassing: (a) combined immunodeficiencies; (b) primarily antibody deficiencies; (c) phagocyte disorders; (d) other well-defined immunodeficiency syndromes; and (e) complement deficiencies. Currently there are greater than 95 unique primary immunodeficiency diseases that fall into these five groups. The more common disorders in each of the first four groups will be reviewed in terms of: (a) individual diseases and their molecular etiologies; (b) diagnostic criteria that may include flow cytometry; and (c) our laboratory's own experience in the development and utilization of flow cytometry based assays for the diagnosis of primary immune deficiency disease including histograms of specific cases.
ISSN:1529-1049
DOI:10.1016/S1529-1049(02)00054-5