Identification of nucleotides by measuring their current during DNA translocation through a nanopore

The electrical current through nucleotide junctions (guanine [G], cytosine [C], adenine [A], and thymine [T] bases sandwiched between Ag atoms) was calculated using the electron propagator theory (Keldysh–Green function formalism). The magnitudes of the calculated currents change in the following hi...

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Bibliographic Details
Published in:Russian chemical bulletin 2015-10, Vol.64 (10), p.2325-2329
Main Authors: Kletsov, A. A., Kosolapova, K. I., Chumakov, A. S., Glukhova, V. A., Mikhailov, A. I., Glukhovskoi, E. G.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Inorganic Chemistry
Organic Chemistry
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Summary:The electrical current through nucleotide junctions (guanine [G], cytosine [C], adenine [A], and thymine [T] bases sandwiched between Ag atoms) was calculated using the electron propagator theory (Keldysh–Green function formalism). The magnitudes of the calculated currents change in the following hierarchy: I A > I G > I C > I T . The difference in the current magnitudes implies the possibility of nucleotide identification by measuring the current they conduct during DNA translocation through a nanopore.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-015-1159-0